@article{78746d121cfa4e8c9ffb86674c550af3,
title = "Ocular amyloid imaging at the crossroad of Alzheimer{\textquoteright}s disease and age-related macular degeneration: implications for diagnosis and therapy",
abstract = "Alzheimer{\textquoteright}s disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in the retina in both AD and AMD. While current diagnostic modalities for detecting Aβ in the brain are costly or invasive, Aβ in the retina can be noninvasively and conveniently imaged using modern photonic imaging systems such as optical coherence tomography (OCT). Moreover, since many of these retinal changes occur before degenerative changes can be detected in the brain, ocular amyloid biomarkers could be utilized to detect AD as well as AMD in their earliest stages when therapy may be most effective in halting disease progression. Novel technologies to quantify retinal biomarkers have the potential to facilitate early diagnosis and noninvasive monitoring of disease progression with important therapeutic implications.",
keywords = "Alzheimer{\textquoteright}s disease, Amyloid beta, Optical coherence tomography, Retinal imaging",
author = "Ong, {Sally S.} and Proia, {Alan D.} and Whitson, {Heather E.} and Sina Farsiu and Doraiswamy, {P. Murali} and Lad, {Eleonora M.}",
note = "Funding Information: Conflicts of interest SSO receives research funding from the International Retinal Research Foundation. EML has received research grants from Alzheimer{\textquoteright}s Association, Duke Institute for Brain Sciences and the National Eye Institute. HEW has received research grants from the Veterans Affairs Medical Center, National Institute on Aging and Alzheimer{\textquoteright}s Association. SF has received research grants from the National Institute of Health and Duke University, and holds US patent 8811745 and 9299155. PMD has received advisory fees from Avid/ Lilly, Anthrotronix, Muses Labs, AstraZeneca, Cognoptix, Lundbeck/ Takeda, Piramal, Genomind, Sonexa, Targacept, NeuroPro, Neuro-cog Trials, Forum, Holmusk, and T3D Therapeutics; research grants Publisher Copyright: {\textcopyright} 2018, Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2019",
month = jul,
day = "1",
doi = "10.1007/s00415-018-9028-z",
language = "English (US)",
volume = "266",
pages = "1566--1577",
journal = "Journal of neurology",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "7",
}