Ocular amyloid imaging at the crossroad of Alzheimer’s disease and age-related macular degeneration: implications for diagnosis and therapy

Sally Ong, Alan D. Proia, Heather E. Whitson, Sina Farsiu, P. Murali Doraiswamy, Eleonora M. Lad

Research output: Contribution to journalArticle

Abstract

Alzheimer’s disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in the retina in both AD and AMD. While current diagnostic modalities for detecting Aβ in the brain are costly or invasive, Aβ in the retina can be noninvasively and conveniently imaged using modern photonic imaging systems such as optical coherence tomography (OCT). Moreover, since many of these retinal changes occur before degenerative changes can be detected in the brain, ocular amyloid biomarkers could be utilized to detect AD as well as AMD in their earliest stages when therapy may be most effective in halting disease progression. Novel technologies to quantify retinal biomarkers have the potential to facilitate early diagnosis and noninvasive monitoring of disease progression with important therapeutic implications.

Original languageEnglish (US)
JournalJournal of Neurology
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Macular Degeneration
Amyloid
Alzheimer Disease
Disease Progression
Retina
Brain
Biomarkers
Optics and Photonics
Optical Coherence Tomography
Therapeutics
Early Diagnosis
Technology

Keywords

  • Alzheimer’s disease
  • Amyloid beta
  • Optical coherence tomography
  • Retinal imaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Ocular amyloid imaging at the crossroad of Alzheimer’s disease and age-related macular degeneration : implications for diagnosis and therapy. / Ong, Sally; Proia, Alan D.; Whitson, Heather E.; Farsiu, Sina; Doraiswamy, P. Murali; Lad, Eleonora M.

In: Journal of Neurology, 01.01.2018.

Research output: Contribution to journalArticle

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