OCT imaging of the musculoskeletal and cardiovascular systems

Xingde Li, Debra Stamper, Nirlep Patel, Kathleen Saunders, Sam Plummer, John Schenck, Ika Rogowska, James Fujimoto, Mark Brezinski

Research output: Contribution to journalArticle


In this presentation, the application of optical coherence tomography (OCT) to the prevention of myocardial infarction and early identification of osteoarthritis is discussed. Myocardial infarction or a heart attack is the leading cause of death worldwide. It results from an acute loss of blood flow to a region of the heart resulting in death to that heart tissue. Most heart attacks are caused by small, thin walled lipid filled plaques which can not be detected by currently available imaging technologies. This paper outlines some of the advances demonstrating the potential of OCT for the identification of high risk plaque. Osteoarthritis is a major cause of morbidity in the industrialized world. The hallmark of the disease is a degradation of articular cartilage. As new therapeutics have been shown to be effective in animal models, there effectiveness in humans remains unclear as there is no effective method for accurate monitoring changes in cartilage. In the second part of this manuscript, the effectiveness of OCT for monitoring articular cartilage is described.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalProceedings of SPIE-The International Society for Optical Engineering
StatePublished - 2002


  • High frequency ultrasound
  • Optical Coherence Tomography
  • Osteoarthritis
  • Plaque rupture

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Li, X., Stamper, D., Patel, N., Saunders, K., Plummer, S., Schenck, J., Rogowska, I., Fujimoto, J., & Brezinski, M. (2002). OCT imaging of the musculoskeletal and cardiovascular systems. Proceedings of SPIE-The International Society for Optical Engineering, 4707, 9-15. https://doi.org/10.1117/12.475604