OCT imaging of osteoarthritic cartilage: Structure, polarization sensitivity, and clinical feasibility

Xingde Li, Jurgen Herrmann, Ravi Ghanta, Costas Pitris, Wolfgang Drexler, Christine Jesser, Debra Stamper, David Golden, Scott Martin, James G. Fujimoto, Mark Brezinski

Research output: Contribution to journalConference article

Abstract

This work demonstrates the feasibility of Optical Coherence Tomography (OCT) for identifying early osteoarthritic pathology. In addition to structural abnormalities, changes in collagen fiber organization, an indicator of very early osteoarthritis, were assessed with a polarization sensitive OCT system. A portable, real time, modular OCT system, suitable for both laboratory and clinical settings, has been developed. Preliminary in vivo imaging results obtained during partial knee replacement surgery are discussed.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3598
StatePublished - Jan 1 1999
EventProceedings of the 1999 Coherence Domain Optical Methods in Biomedical Science and Clinical Applications III - San Jose, CA, USA
Duration: Jan 27 1999Jan 29 1999

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Li, X., Herrmann, J., Ghanta, R., Pitris, C., Drexler, W., Jesser, C., Stamper, D., Golden, D., Martin, S., Fujimoto, J. G., & Brezinski, M. (1999). OCT imaging of osteoarthritic cartilage: Structure, polarization sensitivity, and clinical feasibility. Proceedings of SPIE - The International Society for Optical Engineering, 3598, 152-157.