TY - JOUR
T1 - Occurrence of shigellosis in the young and elderly in rural China
T2 - Results of a 12-month population-based surveillance study
AU - Wang, Xuan Yi
AU - Du, Lin
AU - Von Seidlein, Lorenz
AU - Xu, Zhi Yi
AU - Zhang, Ying Lin
AU - Hao, Zhi Yong
AU - Han, Oak Pil
AU - Ma, Jing Chen
AU - Lee, Hye Jon
AU - Ali, Mohammad
AU - Han, Chang Quan
AU - Xing, Zhan Chun
AU - Chen, Ji Chao
AU - Clemens, John
PY - 2005/8
Y1 - 2005/8
N2 - In 2002, population- and treatment center-based surveillance was used to study the disease burden of shigellosis in rural Hebei Province in the People's Republic of China. A total of 10,105 children with diarrhea or dysentery were enrolled. Infants were treated most frequently for diarrhea (1,388/1,000/year) followed by children ≤ 5 years old (618/1,000/year). Shigellosis was treated most often in children 3-4 years old (32/1,000/year) and people > 60 years of age (7/1,000/year). Fifty-six percent (184 of 331) Shigella isolates were detected in patients who had non-bloody diarrhea. Shigella flexneri was identified in 93% of 306 isolates. The most common S. flexneri serotypes were 1a (34%), X (33%), and 2a (28%). More than 90% of the Shigella isolates were resistant to cotrimoxazole and nalidixic acid, but remained susceptible to ciprofloxacin, norfloxacin, and gentamicin. Widespread resistance to antibiotics adds urgency to the development and use of vaccines to control shigellosis.
AB - In 2002, population- and treatment center-based surveillance was used to study the disease burden of shigellosis in rural Hebei Province in the People's Republic of China. A total of 10,105 children with diarrhea or dysentery were enrolled. Infants were treated most frequently for diarrhea (1,388/1,000/year) followed by children ≤ 5 years old (618/1,000/year). Shigellosis was treated most often in children 3-4 years old (32/1,000/year) and people > 60 years of age (7/1,000/year). Fifty-six percent (184 of 331) Shigella isolates were detected in patients who had non-bloody diarrhea. Shigella flexneri was identified in 93% of 306 isolates. The most common S. flexneri serotypes were 1a (34%), X (33%), and 2a (28%). More than 90% of the Shigella isolates were resistant to cotrimoxazole and nalidixic acid, but remained susceptible to ciprofloxacin, norfloxacin, and gentamicin. Widespread resistance to antibiotics adds urgency to the development and use of vaccines to control shigellosis.
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U2 - 10.4269/ajtmh.2005.73.416
DO - 10.4269/ajtmh.2005.73.416
M3 - Article
C2 - 16103614
AN - SCOPUS:24644440535
SN - 0002-9637
VL - 73
SP - 416
EP - 422
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 2
ER -