Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression

Donald R. Hoover, Yun Peng, Alfred Saah, Richard David Semba, Roger R. Detels, Charles R. Rinaldo, John P. Phair

Research output: Contribution to journalArticle

Abstract

Objective: To estimate the incidence and prevalence of cytomegalovirus retinitis (CMV-R) in late-stage human immunodeficiency virus type 1 disease. Design: Cohort study. Setting: The Multicenter AIDS Cohort Study, an ongoing 10-year study of human immunodeficiency virus type 1-infected homosexual men with semiannual visits and CD4 + cell testing. Study Participants: Three hundred sixty-seven human immunodeficiency virus type 1-infected men from the Multicenter AIDS Cohort Study who were receiving zidovudine and Pneumocystis carinii prophylaxis and who had CD4 + cell counts fall below 0.10x10 9/L (100/μL). Main Outcome Measures: Kaplan-Meier-type estimates for various longitudinal quantifications of incidence and prevalence of CMV-R were obtained. Results: Among these 367 individuals, cytomegalovirus disease developed in 103, of whom 73 (71%) had ocular complications. At 4 years after the first CD4 cell count (9/L), the probability for these subjects to have (1) remained living without CMV-R was 11%, (2) died without experiencing CMV-R was 66%, (3) experienced CMV-R and be living was 6%, and (4) experienced CMV-R and died was 18%. During these 4 years, there was a 25% chance for the development of CMV-R and, on average, 0.211 person-years of CMV-R morbidity. Among those subjects in whom CMV-R developed, about 19% did have CMV-R before a CD4 + cell count of less than 0.05x10 9/L (+ cell count reached this threshold. Conclusion: These estimates may be relevant to current clinical practice and help in allocating resources and planning for treatment and prophylaxis against cytomegalovirus disease.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalArchives of Ophthalmology
Volume114
Issue number7
StatePublished - Jul 1996

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Cytomegalovirus Retinitis
Immunosuppression
HIV
CD4 Lymphocyte Count
HIV-1
Cohort Studies
Cytomegalovirus
Acquired Immunodeficiency Syndrome
Pneumocystis carinii
Zidovudine
Incidence
Kaplan-Meier Estimate
Virus Diseases
Cell Count
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Hoover, D. R., Peng, Y., Saah, A., Semba, R. D., Detels, R. R., Rinaldo, C. R., & Phair, J. P. (1996). Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. Archives of Ophthalmology, 114(7), 821-827.

Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. / Hoover, Donald R.; Peng, Yun; Saah, Alfred; Semba, Richard David; Detels, Roger R.; Rinaldo, Charles R.; Phair, John P.

In: Archives of Ophthalmology, Vol. 114, No. 7, 07.1996, p. 821-827.

Research output: Contribution to journalArticle

Hoover, DR, Peng, Y, Saah, A, Semba, RD, Detels, RR, Rinaldo, CR & Phair, JP 1996, 'Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression', Archives of Ophthalmology, vol. 114, no. 7, pp. 821-827.
Hoover, Donald R. ; Peng, Yun ; Saah, Alfred ; Semba, Richard David ; Detels, Roger R. ; Rinaldo, Charles R. ; Phair, John P. / Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. In: Archives of Ophthalmology. 1996 ; Vol. 114, No. 7. pp. 821-827.
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