Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma

Jie Jiao, Tongzhang Zheng, Qing Lan, Yingtai Chen, Qian Deng, Xiaofeng Bi, Christopher Kim, Theodore Holford, Brian Leaderer, Peter Boyle, Yue Ba, Zhaolin Xia, Stephen J. Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

The main objective of this study was to test the hypothesis that genetic variations in DNA repair genes may modify the association between occupational exposure to solvents and the risk of non-Hodgkin's lymphoma (NHL). A population-based case-control study was conducted on Connecticut women including 518 histologically confirmed incident NHL cases and 597 controls. Unconditional logistic regression models were used to estimate the odds ratios and effect modification from the 30 single nucleotide polymorphisms in 16 DNA repair genes of the association between solvent exposure and the risk of NHL overall and subtypes. Single nucleotide polymorphisms in MGMT (rs12917) and NBS1 (rs1805794) significantly modified the association between exposure to chlorinated solvents and the risk of NHL (Pfor interaction=0.0003 and 0.0048, respectively). After stratification by major NHL histological subtypes, MGMT (rs12917) modified the association between chlorinated solvents and the risk of diffuse large B-cell lymphoma (Pfor interaction=0.0027) and follicular lymphoma (Pfor interaction=0.0024). A significant interaction was also observed between occupational exposure to benzene and BRCA2 (rs144848) for NHL overall (Pfor interaction=0.0042). Our study results suggest that genetic variations in DNA repair genes modify the association between occupational exposure to solvents and the risk of NHL.

Original languageEnglish (US)
Pages (from-to)580-584
Number of pages5
JournalEuropean Journal of Cancer Prevention
Volume21
Issue number6
DOIs
StatePublished - Nov 2012

Keywords

  • DNA repair genes
  • Non-Hodgkin's lymphoma
  • Occupational exposure
  • Single nucleotide polymorphism
  • Solvents

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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