Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma

Jie Jiao, Tongzhang Zheng, Qing Lan, Yingtai Chen, Qian Deng, Xiaofeng Bi, Christopher Kim, Theodore Holford, Brian Leaderer, Peter Boyle, Yue Ba, Zhaolin Xia, Stephen J. Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticle

Abstract

The main objective of this study was to test the hypothesis that genetic variations in DNA repair genes may modify the association between occupational exposure to solvents and the risk of non-Hodgkin's lymphoma (NHL). A population-based case-control study was conducted on Connecticut women including 518 histologically confirmed incident NHL cases and 597 controls. Unconditional logistic regression models were used to estimate the odds ratios and effect modification from the 30 single nucleotide polymorphisms in 16 DNA repair genes of the association between solvent exposure and the risk of NHL overall and subtypes. Single nucleotide polymorphisms in MGMT (rs12917) and NBS1 (rs1805794) significantly modified the association between exposure to chlorinated solvents and the risk of NHL (Pfor interaction=0.0003 and 0.0048, respectively). After stratification by major NHL histological subtypes, MGMT (rs12917) modified the association between chlorinated solvents and the risk of diffuse large B-cell lymphoma (Pfor interaction=0.0027) and follicular lymphoma (Pfor interaction=0.0024). A significant interaction was also observed between occupational exposure to benzene and BRCA2 (rs144848) for NHL overall (Pfor interaction=0.0042). Our study results suggest that genetic variations in DNA repair genes modify the association between occupational exposure to solvents and the risk of NHL.

Original languageEnglish (US)
Pages (from-to)580-584
Number of pages5
JournalEuropean Journal of Cancer Prevention
Volume21
Issue number6
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Occupational Exposure
DNA Repair
Non-Hodgkin's Lymphoma
Genes
Single Nucleotide Polymorphism
Logistic Models
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
Benzene
Case-Control Studies
Odds Ratio
Population

Keywords

  • DNA repair genes
  • Non-Hodgkin's lymphoma
  • Occupational exposure
  • Single nucleotide polymorphism
  • Solvents

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma. / Jiao, Jie; Zheng, Tongzhang; Lan, Qing; Chen, Yingtai; Deng, Qian; Bi, Xiaofeng; Kim, Christopher; Holford, Theodore; Leaderer, Brian; Boyle, Peter; Ba, Yue; Xia, Zhaolin; Chanock, Stephen J.; Rothman, Nathaniel; Zhang, Yawei.

In: European Journal of Cancer Prevention, Vol. 21, No. 6, 11.2012, p. 580-584.

Research output: Contribution to journalArticle

Jiao, J, Zheng, T, Lan, Q, Chen, Y, Deng, Q, Bi, X, Kim, C, Holford, T, Leaderer, B, Boyle, P, Ba, Y, Xia, Z, Chanock, SJ, Rothman, N & Zhang, Y 2012, 'Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma', European Journal of Cancer Prevention, vol. 21, no. 6, pp. 580-584. https://doi.org/10.1097/CEJ.0b013e328351c762
Jiao, Jie ; Zheng, Tongzhang ; Lan, Qing ; Chen, Yingtai ; Deng, Qian ; Bi, Xiaofeng ; Kim, Christopher ; Holford, Theodore ; Leaderer, Brian ; Boyle, Peter ; Ba, Yue ; Xia, Zhaolin ; Chanock, Stephen J. ; Rothman, Nathaniel ; Zhang, Yawei. / Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma. In: European Journal of Cancer Prevention. 2012 ; Vol. 21, No. 6. pp. 580-584.
@article{6df60bc8caf844089add478b46bea04f,
title = "Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma",
abstract = "The main objective of this study was to test the hypothesis that genetic variations in DNA repair genes may modify the association between occupational exposure to solvents and the risk of non-Hodgkin's lymphoma (NHL). A population-based case-control study was conducted on Connecticut women including 518 histologically confirmed incident NHL cases and 597 controls. Unconditional logistic regression models were used to estimate the odds ratios and effect modification from the 30 single nucleotide polymorphisms in 16 DNA repair genes of the association between solvent exposure and the risk of NHL overall and subtypes. Single nucleotide polymorphisms in MGMT (rs12917) and NBS1 (rs1805794) significantly modified the association between exposure to chlorinated solvents and the risk of NHL (Pfor interaction=0.0003 and 0.0048, respectively). After stratification by major NHL histological subtypes, MGMT (rs12917) modified the association between chlorinated solvents and the risk of diffuse large B-cell lymphoma (Pfor interaction=0.0027) and follicular lymphoma (Pfor interaction=0.0024). A significant interaction was also observed between occupational exposure to benzene and BRCA2 (rs144848) for NHL overall (Pfor interaction=0.0042). Our study results suggest that genetic variations in DNA repair genes modify the association between occupational exposure to solvents and the risk of NHL.",
keywords = "DNA repair genes, Non-Hodgkin's lymphoma, Occupational exposure, Single nucleotide polymorphism, Solvents",
author = "Jie Jiao and Tongzhang Zheng and Qing Lan and Yingtai Chen and Qian Deng and Xiaofeng Bi and Christopher Kim and Theodore Holford and Brian Leaderer and Peter Boyle and Yue Ba and Zhaolin Xia and Chanock, {Stephen J.} and Nathaniel Rothman and Yawei Zhang",
year = "2012",
month = "11",
doi = "10.1097/CEJ.0b013e328351c762",
language = "English (US)",
volume = "21",
pages = "580--584",
journal = "European Journal of Cancer Prevention",
issn = "0959-8278",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma

AU - Jiao, Jie

AU - Zheng, Tongzhang

AU - Lan, Qing

AU - Chen, Yingtai

AU - Deng, Qian

AU - Bi, Xiaofeng

AU - Kim, Christopher

AU - Holford, Theodore

AU - Leaderer, Brian

AU - Boyle, Peter

AU - Ba, Yue

AU - Xia, Zhaolin

AU - Chanock, Stephen J.

AU - Rothman, Nathaniel

AU - Zhang, Yawei

PY - 2012/11

Y1 - 2012/11

N2 - The main objective of this study was to test the hypothesis that genetic variations in DNA repair genes may modify the association between occupational exposure to solvents and the risk of non-Hodgkin's lymphoma (NHL). A population-based case-control study was conducted on Connecticut women including 518 histologically confirmed incident NHL cases and 597 controls. Unconditional logistic regression models were used to estimate the odds ratios and effect modification from the 30 single nucleotide polymorphisms in 16 DNA repair genes of the association between solvent exposure and the risk of NHL overall and subtypes. Single nucleotide polymorphisms in MGMT (rs12917) and NBS1 (rs1805794) significantly modified the association between exposure to chlorinated solvents and the risk of NHL (Pfor interaction=0.0003 and 0.0048, respectively). After stratification by major NHL histological subtypes, MGMT (rs12917) modified the association between chlorinated solvents and the risk of diffuse large B-cell lymphoma (Pfor interaction=0.0027) and follicular lymphoma (Pfor interaction=0.0024). A significant interaction was also observed between occupational exposure to benzene and BRCA2 (rs144848) for NHL overall (Pfor interaction=0.0042). Our study results suggest that genetic variations in DNA repair genes modify the association between occupational exposure to solvents and the risk of NHL.

AB - The main objective of this study was to test the hypothesis that genetic variations in DNA repair genes may modify the association between occupational exposure to solvents and the risk of non-Hodgkin's lymphoma (NHL). A population-based case-control study was conducted on Connecticut women including 518 histologically confirmed incident NHL cases and 597 controls. Unconditional logistic regression models were used to estimate the odds ratios and effect modification from the 30 single nucleotide polymorphisms in 16 DNA repair genes of the association between solvent exposure and the risk of NHL overall and subtypes. Single nucleotide polymorphisms in MGMT (rs12917) and NBS1 (rs1805794) significantly modified the association between exposure to chlorinated solvents and the risk of NHL (Pfor interaction=0.0003 and 0.0048, respectively). After stratification by major NHL histological subtypes, MGMT (rs12917) modified the association between chlorinated solvents and the risk of diffuse large B-cell lymphoma (Pfor interaction=0.0027) and follicular lymphoma (Pfor interaction=0.0024). A significant interaction was also observed between occupational exposure to benzene and BRCA2 (rs144848) for NHL overall (Pfor interaction=0.0042). Our study results suggest that genetic variations in DNA repair genes modify the association between occupational exposure to solvents and the risk of NHL.

KW - DNA repair genes

KW - Non-Hodgkin's lymphoma

KW - Occupational exposure

KW - Single nucleotide polymorphism

KW - Solvents

UR - http://www.scopus.com/inward/record.url?scp=84867033419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867033419&partnerID=8YFLogxK

U2 - 10.1097/CEJ.0b013e328351c762

DO - 10.1097/CEJ.0b013e328351c762

M3 - Article

C2 - 22430443

AN - SCOPUS:84867033419

VL - 21

SP - 580

EP - 584

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

SN - 0959-8278

IS - 6

ER -