Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma

Qian Deng, Tongzhang Zheng, Qing Lan, Yajia Lan, Theodore Holford, Yingtai Chen, Min Dai, Brian Leaderer, Peter Boyle, Stephen J. Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticle

Abstract

Solvent exposure has been inconsistently linked to the risk for non-Hodgkin lymphoma (NHL). The aim of this study was to determine whether the association is modified by genetic variation in immune genes. A population-based case-control study involving 601 incident cases of NHL and 717 controls was carried out in 1996-2000 among women from Connecticut. Thirty single nucleotide polymorphisms in 17 immune genes were examined in relation to the associations between exposure to various solvents and the risk for NHL. The study found that polymorphism in interleukin 10 (IL10; rs1800890) modified the association between occupational exposure to organic solvents and the risk for diffuse large B-cell lymphoma (Pfor interaction=0.0058). The results remained statistically significant after adjustment for false discovery rate. Compared with women who were never occupationally exposed to any organic solvents, women who were exposed to organic solvents at least once had a significantly increased risk for diffuse large B-cell lymphoma if they carried the IL10 (rs1800890) TT genotype (odds ratio=3.31, 95% confidence interval: 1.80-6.08), but not if they carried the AT/AA genotype (odds ratio=1.14, 95% confidence interval: 0.72-1.79). No significant interactions were observed for other immune gene single nucleotide polymorphisms and various solvents in relation to NHL overall and its major subtypes. The study provided preliminary evidence supporting a role of immune gene variations in modifying the association between occupational solvent exposure and the risk for NHL.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume22
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Occupational Exposure
Non-Hodgkin's Lymphoma
Genes
Interleukin-10
Lymphoma, Large B-Cell, Diffuse
Single Nucleotide Polymorphism
Odds Ratio
Genotype
Confidence Intervals
Case-Control Studies
Population

Keywords

  • immune genes
  • non-Hodgkin lymphoma
  • occupational exposure
  • single nucleotide polymorphism
  • solvents

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma. / Deng, Qian; Zheng, Tongzhang; Lan, Qing; Lan, Yajia; Holford, Theodore; Chen, Yingtai; Dai, Min; Leaderer, Brian; Boyle, Peter; Chanock, Stephen J.; Rothman, Nathaniel; Zhang, Yawei.

In: European Journal of Cancer Prevention, Vol. 22, No. 1, 01.2013, p. 77-82.

Research output: Contribution to journalArticle

Deng, Q, Zheng, T, Lan, Q, Lan, Y, Holford, T, Chen, Y, Dai, M, Leaderer, B, Boyle, P, Chanock, SJ, Rothman, N & Zhang, Y 2013, 'Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma', European Journal of Cancer Prevention, vol. 22, no. 1, pp. 77-82. https://doi.org/10.1097/CEJ.0b013e328354d2c1
Deng, Qian ; Zheng, Tongzhang ; Lan, Qing ; Lan, Yajia ; Holford, Theodore ; Chen, Yingtai ; Dai, Min ; Leaderer, Brian ; Boyle, Peter ; Chanock, Stephen J. ; Rothman, Nathaniel ; Zhang, Yawei. / Occupational solvent exposure, genetic variation in immune genes, and the risk for non-Hodgkin lymphoma. In: European Journal of Cancer Prevention. 2013 ; Vol. 22, No. 1. pp. 77-82.
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