Occult pulmonary synovial sarcoma confirmed by molecular techniques

Research output: Contribution to journalArticle

Abstract

We report a unique case of a minute, occult synovial sarcoma of the lung detected intraoperatively during a pneumothorax repair in a 17-year-old boy. No alternative primary site could be detected upon complete body imaging studies and physical examinations. The diagnosis was confirmed by demonstration of the characteristic SYT/SSX gene fusion by reverse transcriptase polymerase chain reaction (RT-PCR) performed upon RNA extracted from the paraffin block of the biopsy. This case demonstrates the utility of this technique in diagnostic pathology.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalPediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Volume3
Issue number1
DOIs
StatePublished - Jan 2000

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Synovial Sarcoma
Gene Fusion
Pneumothorax
Reverse Transcriptase Polymerase Chain Reaction
Paraffin
Physical Examination
RNA
Pathology
Biopsy
Lung

Keywords

  • Polymerase chain reaction
  • Reverse transcriptase
  • Synovial sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

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keywords = "Polymerase chain reaction, Reverse transcriptase, Synovial sarcoma",
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AB - We report a unique case of a minute, occult synovial sarcoma of the lung detected intraoperatively during a pneumothorax repair in a 17-year-old boy. No alternative primary site could be detected upon complete body imaging studies and physical examinations. The diagnosis was confirmed by demonstration of the characteristic SYT/SSX gene fusion by reverse transcriptase polymerase chain reaction (RT-PCR) performed upon RNA extracted from the paraffin block of the biopsy. This case demonstrates the utility of this technique in diagnostic pathology.

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