Occult primary cancer: Clinical practice guidelines

David S Ettinger, Juan P. Arnoletti, Jon P. Gockerman, Charles Handorf, Kathleen Anne Havlin, Charlotte D. Jacobs, Milind Javle, Larry Kvols, Renato Lenzi, Asif Rashid, Chris A. Rhoades, John A. Ridge, Leonard Saltz, Lawrence N. Shulman, Vernon K. Sondak, John A. Thompson, Przemyslaw Twardowski, Weining Zhen

Research output: Contribution to journalArticle

Abstract

Occult primary tumors, or cancers of unknown primary site, account for 5% to 10% of all diagnosed cancers. These tumors are manifested by a wide variety of clinical presentations, and for most patients, the disease is incurable. Multiple sites of involvement are shown in more than 50% of patients with occult primary tumors. Common sites of involvement are the liver, lungs, bones, and lymph nodes. Life expectancy is very short, with a median survival of about 6 to 9 months. Given the uncertainties and the generally poor prognosis, patients frequently experience significant psychosocial distress, and empathetic discussion about the natural history of these types of cancers and their prognosis is required. Patient and family education, support, and counseling by the primary oncology team and referral to specialized psychosocial services may help to alleviate this distress.

Original languageEnglish (US)
Pages (from-to)214-233
Number of pages20
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume3
Issue number2
StatePublished - Mar 2005

Fingerprint

Practice Guidelines
Neoplasms
Patient Education
Life Expectancy
Natural History
Uncertainty
Counseling
Referral and Consultation
Lymph Nodes
Bone and Bones
Lung
Survival
Liver

Keywords

  • Carcinoma
  • Chemotherapy
  • Diagnosis
  • Metastasis
  • NCCN Clinical Practice Guidelines
  • Occult primary disease

ASJC Scopus subject areas

  • Oncology

Cite this

Ettinger, D. S., Arnoletti, J. P., Gockerman, J. P., Handorf, C., Havlin, K. A., Jacobs, C. D., ... Zhen, W. (2005). Occult primary cancer: Clinical practice guidelines. JNCCN Journal of the National Comprehensive Cancer Network, 3(2), 214-233.

Occult primary cancer : Clinical practice guidelines. / Ettinger, David S; Arnoletti, Juan P.; Gockerman, Jon P.; Handorf, Charles; Havlin, Kathleen Anne; Jacobs, Charlotte D.; Javle, Milind; Kvols, Larry; Lenzi, Renato; Rashid, Asif; Rhoades, Chris A.; Ridge, John A.; Saltz, Leonard; Shulman, Lawrence N.; Sondak, Vernon K.; Thompson, John A.; Twardowski, Przemyslaw; Zhen, Weining.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 3, No. 2, 03.2005, p. 214-233.

Research output: Contribution to journalArticle

Ettinger, DS, Arnoletti, JP, Gockerman, JP, Handorf, C, Havlin, KA, Jacobs, CD, Javle, M, Kvols, L, Lenzi, R, Rashid, A, Rhoades, CA, Ridge, JA, Saltz, L, Shulman, LN, Sondak, VK, Thompson, JA, Twardowski, P & Zhen, W 2005, 'Occult primary cancer: Clinical practice guidelines', JNCCN Journal of the National Comprehensive Cancer Network, vol. 3, no. 2, pp. 214-233.
Ettinger DS, Arnoletti JP, Gockerman JP, Handorf C, Havlin KA, Jacobs CD et al. Occult primary cancer: Clinical practice guidelines. JNCCN Journal of the National Comprehensive Cancer Network. 2005 Mar;3(2):214-233.
Ettinger, David S ; Arnoletti, Juan P. ; Gockerman, Jon P. ; Handorf, Charles ; Havlin, Kathleen Anne ; Jacobs, Charlotte D. ; Javle, Milind ; Kvols, Larry ; Lenzi, Renato ; Rashid, Asif ; Rhoades, Chris A. ; Ridge, John A. ; Saltz, Leonard ; Shulman, Lawrence N. ; Sondak, Vernon K. ; Thompson, John A. ; Twardowski, Przemyslaw ; Zhen, Weining. / Occult primary cancer : Clinical practice guidelines. In: JNCCN Journal of the National Comprehensive Cancer Network. 2005 ; Vol. 3, No. 2. pp. 214-233.
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