Occult intracranial aneurysms in polycystic kidney disease: Screening with MR angiography

Paul M. Ruggieri, Nicholas Poulos, Thomas J. Masaryk, Jeffrey S. Ross, Nancy A. Obuchowski, Issam A. Awad, William E. Braun, Joseph Nally, Jonathan S. Lewin, Michael T. Modic

Research output: Contribution to journalArticle

Abstract

PURPOSE: To estimate the prevalence, location, and type of cerebral aneurysms in patients with adult polycystic kidney disease (PCKD) and identify associated risk factors. MATERIALS AND METHODS: Ninety-three patients with PCKD were screened for aneurysms with spin-echo parenchymal magnetic resonance (MR) imaging and three-dimensional time-of-flight MR angiography. Prevalence was estimated with the calculated proportions of patients who had aneurysms, adjusted for reported sensitivity and specificity of MR angiography. RESULTS: Thirteen aneurysms, found in 10 patients, were 7 mm or smaller in largest dimension; 11 of these aneurysms were saccular. Intra- and interobserver variabilities were 96%-98%. Conventional arteriograms, obtained in six patients, helped confirm the MR angiographic findings. The best estimates of prevalence of aneurysms were 11.7% in the study group (n = 93) and 25.8% in patients with a family history of aneurysms (n = 6). CONCLUSION: The prevalence of aneurysms in the study group was greater than in the general population. MR angiography is useful in screening for cerebral aneurysms.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalRadiology
Volume191
Issue number1
StatePublished - Apr 1994
Externally publishedYes

Fingerprint

Polycystic Kidney Diseases
Magnetic Resonance Angiography
Intracranial Aneurysm
Aneurysm
Autosomal Dominant Polycystic Kidney
Observer Variation
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Sensitivity and Specificity
Population

Keywords

  • Aneurysm, cerebral
  • Kidney, cysts
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Ruggieri, P. M., Poulos, N., Masaryk, T. J., Ross, J. S., Obuchowski, N. A., Awad, I. A., ... Modic, M. T. (1994). Occult intracranial aneurysms in polycystic kidney disease: Screening with MR angiography. Radiology, 191(1), 33-39.

Occult intracranial aneurysms in polycystic kidney disease : Screening with MR angiography. / Ruggieri, Paul M.; Poulos, Nicholas; Masaryk, Thomas J.; Ross, Jeffrey S.; Obuchowski, Nancy A.; Awad, Issam A.; Braun, William E.; Nally, Joseph; Lewin, Jonathan S.; Modic, Michael T.

In: Radiology, Vol. 191, No. 1, 04.1994, p. 33-39.

Research output: Contribution to journalArticle

Ruggieri, PM, Poulos, N, Masaryk, TJ, Ross, JS, Obuchowski, NA, Awad, IA, Braun, WE, Nally, J, Lewin, JS & Modic, MT 1994, 'Occult intracranial aneurysms in polycystic kidney disease: Screening with MR angiography', Radiology, vol. 191, no. 1, pp. 33-39.
Ruggieri PM, Poulos N, Masaryk TJ, Ross JS, Obuchowski NA, Awad IA et al. Occult intracranial aneurysms in polycystic kidney disease: Screening with MR angiography. Radiology. 1994 Apr;191(1):33-39.
Ruggieri, Paul M. ; Poulos, Nicholas ; Masaryk, Thomas J. ; Ross, Jeffrey S. ; Obuchowski, Nancy A. ; Awad, Issam A. ; Braun, William E. ; Nally, Joseph ; Lewin, Jonathan S. ; Modic, Michael T. / Occult intracranial aneurysms in polycystic kidney disease : Screening with MR angiography. In: Radiology. 1994 ; Vol. 191, No. 1. pp. 33-39.
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AB - PURPOSE: To estimate the prevalence, location, and type of cerebral aneurysms in patients with adult polycystic kidney disease (PCKD) and identify associated risk factors. MATERIALS AND METHODS: Ninety-three patients with PCKD were screened for aneurysms with spin-echo parenchymal magnetic resonance (MR) imaging and three-dimensional time-of-flight MR angiography. Prevalence was estimated with the calculated proportions of patients who had aneurysms, adjusted for reported sensitivity and specificity of MR angiography. RESULTS: Thirteen aneurysms, found in 10 patients, were 7 mm or smaller in largest dimension; 11 of these aneurysms were saccular. Intra- and interobserver variabilities were 96%-98%. Conventional arteriograms, obtained in six patients, helped confirm the MR angiographic findings. The best estimates of prevalence of aneurysms were 11.7% in the study group (n = 93) and 25.8% in patients with a family history of aneurysms (n = 6). CONCLUSION: The prevalence of aneurysms in the study group was greater than in the general population. MR angiography is useful in screening for cerebral aneurysms.

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