TY - JOUR
T1 - Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism
AU - Drager, Luciano F.
AU - Tavoni, Thauany M.
AU - Silva, Vanessa M.
AU - Santos, Raul D.
AU - Pedrosa, Rodrigo P.
AU - Bortolotto, Luiz A.
AU - Vinagre, Carmen G.
AU - Polotsky, Vsevolod Y.
AU - Lorenzi-Filho, Geraldo
AU - Maranhao, Raul C.
N1 - Publisher Copyright:
Copyright © 2018 Drager et al.
PY - 2018
Y1 - 2018
N2 - This study aimed to explore lipoprotein metabolism in obstructive sleep apnea (OSA) and the effects of continuous positive airway pressure (CPAP). We studied 15 men with severe OSA [apnea-hypopnea index (AHI) ?30 events/ hour] and 12 age-, BMI-, and waist circumference-matched volunteers without OSA (AHI <5 events/hour). Carotid intima- media thickness (CIMT) was determined by a blind examiner. After 12 h fasting, a triglyceride-rich chylomicron-like emulsion, labeled with [14C]cholesteryl oleate and [3H]triolein, was injected intravenously followed by blood sample collection at preestablished times. Fractional clearance rate (FCR) of the radiolabeled lipids was estimated by compartmental analysis of radioisotope decay curves. Compared with controls, patients with OSA showed a significant delay in both cholesteryl ester FCR (0.0126 ± 0.0187 vs. 0.0015 ± 0.0025 min -1 ; P = 0.0313) and triglycerides FCR (0.0334 ± 0.0390 vs. 0.0051 ± 0.0074 min -1 ; P = 0.0001). CIMT was higher in the OSA group: 620 ± 17 vs. 725 ± 29 μm; P = 0.004. Cholesteryl ester FCRs were inversely related to total sleep time <90% (r = -0.463; P = 0.029) and CIMT (r = ?0.601; P = 0.022). The triglyceride FCR was inversely correlated with AHI (r = -0.537; P = 0.04). In a subgroup of patients treated with CPAP for 3 months (n = 7), triglyceride FCR increased 5-fold (P = 0.025), but the cholesteryl ester FCR was unchanged. In conclusion, severe OSA decreased lipolysis of triglyceride-rich lipoproteins and delayed removal of remnants. CPAP treatment may be effective to restore the lipolysis rates.-Drager, L. F., T. M. Tavoni, V. M. Silva, R. D. Santos, R. P. Pedrosa, L. A. Bortolotto, C. G. Vinagre, V. Y. Polotsky, G. Lorenzi-Filho, and R. C. Maranhao. Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism.
AB - This study aimed to explore lipoprotein metabolism in obstructive sleep apnea (OSA) and the effects of continuous positive airway pressure (CPAP). We studied 15 men with severe OSA [apnea-hypopnea index (AHI) ?30 events/ hour] and 12 age-, BMI-, and waist circumference-matched volunteers without OSA (AHI <5 events/hour). Carotid intima- media thickness (CIMT) was determined by a blind examiner. After 12 h fasting, a triglyceride-rich chylomicron-like emulsion, labeled with [14C]cholesteryl oleate and [3H]triolein, was injected intravenously followed by blood sample collection at preestablished times. Fractional clearance rate (FCR) of the radiolabeled lipids was estimated by compartmental analysis of radioisotope decay curves. Compared with controls, patients with OSA showed a significant delay in both cholesteryl ester FCR (0.0126 ± 0.0187 vs. 0.0015 ± 0.0025 min -1 ; P = 0.0313) and triglycerides FCR (0.0334 ± 0.0390 vs. 0.0051 ± 0.0074 min -1 ; P = 0.0001). CIMT was higher in the OSA group: 620 ± 17 vs. 725 ± 29 μm; P = 0.004. Cholesteryl ester FCRs were inversely related to total sleep time <90% (r = -0.463; P = 0.029) and CIMT (r = ?0.601; P = 0.022). The triglyceride FCR was inversely correlated with AHI (r = -0.537; P = 0.04). In a subgroup of patients treated with CPAP for 3 months (n = 7), triglyceride FCR increased 5-fold (P = 0.025), but the cholesteryl ester FCR was unchanged. In conclusion, severe OSA decreased lipolysis of triglyceride-rich lipoproteins and delayed removal of remnants. CPAP treatment may be effective to restore the lipolysis rates.-Drager, L. F., T. M. Tavoni, V. M. Silva, R. D. Santos, R. P. Pedrosa, L. A. Bortolotto, C. G. Vinagre, V. Y. Polotsky, G. Lorenzi-Filho, and R. C. Maranhao. Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism.
KW - Cardiovascular diseases
KW - Chylomicron remnants
KW - Chylomicrons
KW - Clinical studies
KW - Lipid and lipoprotein metabolism
KW - Lipoprotein kinetics
KW - Postprandial lipidemia
UR - http://www.scopus.com/inward/record.url?scp=85048655221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048655221&partnerID=8YFLogxK
U2 - 10.1194/jlr.M083436
DO - 10.1194/jlr.M083436
M3 - Article
C2 - 29628442
AN - SCOPUS:85048655221
SN - 0022-2275
VL - 59
SP - 1027
EP - 1033
JO - Journal of Lipid Research
JF - Journal of Lipid Research
IS - 6
ER -