Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism

Luciano F. Drager, Thauany M. Tavoni, Vanessa M. Silva, Raul D. Santos, Rodrigo P. Pedrosa, Luiz A. Bortolotto, Carmen G. Vinagre, Vsevolod Polotsky, Geraldo Lorenzi-Filho, Raul C. Maranhao

Research output: Contribution to journalArticle

Abstract

This study aimed to explore lipoprotein metabolism in obstructive sleep apnea (OSA) and the effects of continuous positive airway pressure (CPAP). We studied 15 men with severe OSA [apnea-hypopnea index (AHI) ?30 events/ hour] and 12 age-, BMI-, and waist circumference-matched volunteers without OSA (AHI <5 events/hour). Carotid intima- media thickness (CIMT) was determined by a blind examiner. After 12 h fasting, a triglyceride-rich chylomicron-like emulsion, labeled with [14C]cholesteryl oleate and [3H]triolein, was injected intravenously followed by blood sample collection at preestablished times. Fractional clearance rate (FCR) of the radiolabeled lipids was estimated by compartmental analysis of radioisotope decay curves. Compared with controls, patients with OSA showed a significant delay in both cholesteryl ester FCR (0.0126 ± 0.0187 vs. 0.0015 ± 0.0025 min-1; P = 0.0313) and triglycerides FCR (0.0334 ± 0.0390 vs. 0.0051 ± 0.0074 min-1; P = 0.0001). CIMT was higher in the OSA group: 620 ± 17 vs. 725 ± 29 μm; P = 0.004. Cholesteryl ester FCRs were inversely related to total sleep time <90% (r = -0.463; P = 0.029) and CIMT (r = ?0.601; P = 0.022). The triglyceride FCR was inversely correlated with AHI (r = -0.537; P = 0.04). In a subgroup of patients treated with CPAP for 3 months (n = 7), triglyceride FCR increased 5-fold (P = 0.025), but the cholesteryl ester FCR was unchanged. In conclusion, severe OSA decreased lipolysis of triglyceride-rich lipoproteins and delayed removal of remnants. CPAP treatment may be effective to restore the lipolysis rates.-Drager, L. F., T. M. Tavoni, V. M. Silva, R. D. Santos, R. P. Pedrosa, L. A. Bortolotto, C. G. Vinagre, V. Y. Polotsky, G. Lorenzi-Filho, and R. C. Maranhao. Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism.

Original languageEnglish (US)
Pages (from-to)1027-1033
Number of pages7
JournalJournal of Lipid Research
Volume59
Issue number6
DOIs
StatePublished - Jan 1 2018

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Continuous Positive Airway Pressure
Obstructive Sleep Apnea
Metabolism
Lipoproteins
Triglycerides
Carotid Intima-Media Thickness
Cholesterol Esters
Apnea
Lipolysis
Triolein
Chylomicrons
Waist Circumference
Sleep
Emulsions
Radioisotopes
Volunteers
Fasting
Blood
Lipids

Keywords

  • Cardiovascular diseases
  • Chylomicron remnants
  • Chylomicrons
  • Clinical studies
  • Lipid and lipoprotein metabolism
  • Lipoprotein kinetics
  • Postprandial lipidemia

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Drager, L. F., Tavoni, T. M., Silva, V. M., Santos, R. D., Pedrosa, R. P., Bortolotto, L. A., ... Maranhao, R. C. (2018). Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism. Journal of Lipid Research, 59(6), 1027-1033. https://doi.org/10.1194/jlr.M083436

Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism. / Drager, Luciano F.; Tavoni, Thauany M.; Silva, Vanessa M.; Santos, Raul D.; Pedrosa, Rodrigo P.; Bortolotto, Luiz A.; Vinagre, Carmen G.; Polotsky, Vsevolod; Lorenzi-Filho, Geraldo; Maranhao, Raul C.

In: Journal of Lipid Research, Vol. 59, No. 6, 01.01.2018, p. 1027-1033.

Research output: Contribution to journalArticle

Drager, LF, Tavoni, TM, Silva, VM, Santos, RD, Pedrosa, RP, Bortolotto, LA, Vinagre, CG, Polotsky, V, Lorenzi-Filho, G & Maranhao, RC 2018, 'Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism', Journal of Lipid Research, vol. 59, no. 6, pp. 1027-1033. https://doi.org/10.1194/jlr.M083436
Drager, Luciano F. ; Tavoni, Thauany M. ; Silva, Vanessa M. ; Santos, Raul D. ; Pedrosa, Rodrigo P. ; Bortolotto, Luiz A. ; Vinagre, Carmen G. ; Polotsky, Vsevolod ; Lorenzi-Filho, Geraldo ; Maranhao, Raul C. / Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism. In: Journal of Lipid Research. 2018 ; Vol. 59, No. 6. pp. 1027-1033.
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AU - Santos, Raul D.

AU - Pedrosa, Rodrigo P.

AU - Bortolotto, Luiz A.

AU - Vinagre, Carmen G.

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N2 - This study aimed to explore lipoprotein metabolism in obstructive sleep apnea (OSA) and the effects of continuous positive airway pressure (CPAP). We studied 15 men with severe OSA [apnea-hypopnea index (AHI) ?30 events/ hour] and 12 age-, BMI-, and waist circumference-matched volunteers without OSA (AHI <5 events/hour). Carotid intima- media thickness (CIMT) was determined by a blind examiner. After 12 h fasting, a triglyceride-rich chylomicron-like emulsion, labeled with [14C]cholesteryl oleate and [3H]triolein, was injected intravenously followed by blood sample collection at preestablished times. Fractional clearance rate (FCR) of the radiolabeled lipids was estimated by compartmental analysis of radioisotope decay curves. Compared with controls, patients with OSA showed a significant delay in both cholesteryl ester FCR (0.0126 ± 0.0187 vs. 0.0015 ± 0.0025 min-1; P = 0.0313) and triglycerides FCR (0.0334 ± 0.0390 vs. 0.0051 ± 0.0074 min-1; P = 0.0001). CIMT was higher in the OSA group: 620 ± 17 vs. 725 ± 29 μm; P = 0.004. Cholesteryl ester FCRs were inversely related to total sleep time <90% (r = -0.463; P = 0.029) and CIMT (r = ?0.601; P = 0.022). The triglyceride FCR was inversely correlated with AHI (r = -0.537; P = 0.04). In a subgroup of patients treated with CPAP for 3 months (n = 7), triglyceride FCR increased 5-fold (P = 0.025), but the cholesteryl ester FCR was unchanged. In conclusion, severe OSA decreased lipolysis of triglyceride-rich lipoproteins and delayed removal of remnants. CPAP treatment may be effective to restore the lipolysis rates.-Drager, L. F., T. M. Tavoni, V. M. Silva, R. D. Santos, R. P. Pedrosa, L. A. Bortolotto, C. G. Vinagre, V. Y. Polotsky, G. Lorenzi-Filho, and R. C. Maranhao. Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism.

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KW - Chylomicron remnants

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KW - Lipid and lipoprotein metabolism

KW - Lipoprotein kinetics

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