Obstructive nephropathy secondary to sulfasalazine calculi

Paul J. Russinko, Saraub Agarwal, Michael J. Choi, Patrick J. Kelty

Research output: Contribution to journalArticlepeer-review


The incidence of drug-induced stone disease is 0.44%. A 57-year-old woman with ulcerative colitis presented with obstructive nephropathy and pyelonephritis. She underwent cystoscopy, bilateral retrograde pyelography, and bilateral ureteral stent placement. A 6-cm bladder calculus and two 3-mm right distal ureteral calculi were discovered. Later, cystolithotomy was performed. The stone analysis demonstrated sulfapyridine, a sulfasalazine metabolite. Patients with inflammatory bowel disease can develop urolithiasis owing to acidic urine and low-volume urine production. Patients receiving aminosalicylates are at an increased risk of urolithiasis and may benefit from oral hydration and urinary alkalization.

Original languageEnglish (US)
Number of pages1
Issue number4
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Urology

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