Obstructive nephropathy secondary to sulfasalazine calculi

Paul J. Russinko, Saraub Agarwal, Michael J Choi, Patrick J. Kelty

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The incidence of drug-induced stone disease is 0.44%. A 57-year-old woman with ulcerative colitis presented with obstructive nephropathy and pyelonephritis. She underwent cystoscopy, bilateral retrograde pyelography, and bilateral ureteral stent placement. A 6-cm bladder calculus and two 3-mm right distal ureteral calculi were discovered. Later, cystolithotomy was performed. The stone analysis demonstrated sulfapyridine, a sulfasalazine metabolite. Patients with inflammatory bowel disease can develop urolithiasis owing to acidic urine and low-volume urine production. Patients receiving aminosalicylates are at an increased risk of urolithiasis and may benefit from oral hydration and urinary alkalization.

Original languageEnglish (US)
Issue number4
Publication statusPublished - Oct 1 2003
Externally publishedYes


ASJC Scopus subject areas

  • Urology

Cite this

Russinko, P. J., Agarwal, S., Choi, M. J., & Kelty, P. J. (2003). Obstructive nephropathy secondary to sulfasalazine calculi. Urology, 62(4). https://doi.org/10.1016/S0090-4295(03)00666-6