Obstructive nephropathy secondary to sulfasalazine calculi

Paul J. Russinko, Saraub Agarwal, Michael J. Choi, Patrick J. Kelty

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The incidence of drug-induced stone disease is 0.44%. A 57-year-old woman with ulcerative colitis presented with obstructive nephropathy and pyelonephritis. She underwent cystoscopy, bilateral retrograde pyelography, and bilateral ureteral stent placement. A 6-cm bladder calculus and two 3-mm right distal ureteral calculi were discovered. Later, cystolithotomy was performed. The stone analysis demonstrated sulfapyridine, a sulfasalazine metabolite. Patients with inflammatory bowel disease can develop urolithiasis owing to acidic urine and low-volume urine production. Patients receiving aminosalicylates are at an increased risk of urolithiasis and may benefit from oral hydration and urinary alkalization.

Original languageEnglish (US)
Pages (from-to)748
Number of pages1
Issue number4
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Urology


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