Obstructive nephropathy secondary to sulfasalazine calculi

Paul J. Russinko, Saraub Agarwal, Michael J Choi, Patrick J. Kelty

Research output: Contribution to journalArticle

Abstract

The incidence of drug-induced stone disease is 0.44%. A 57-year-old woman with ulcerative colitis presented with obstructive nephropathy and pyelonephritis. She underwent cystoscopy, bilateral retrograde pyelography, and bilateral ureteral stent placement. A 6-cm bladder calculus and two 3-mm right distal ureteral calculi were discovered. Later, cystolithotomy was performed. The stone analysis demonstrated sulfapyridine, a sulfasalazine metabolite. Patients with inflammatory bowel disease can develop urolithiasis owing to acidic urine and low-volume urine production. Patients receiving aminosalicylates are at an increased risk of urolithiasis and may benefit from oral hydration and urinary alkalization.

Original languageEnglish (US)
JournalUrology
Volume62
Issue number4
DOIs
Publication statusPublished - Oct 1 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Urology

Cite this

Russinko, P. J., Agarwal, S., Choi, M. J., & Kelty, P. J. (2003). Obstructive nephropathy secondary to sulfasalazine calculi. Urology, 62(4). https://doi.org/10.1016/S0090-4295(03)00666-6