Obstetric conditions and risk of first admission with schizophrenia

A Danish national register based study

Majella Byrne, Esben Agerbo, Birgit Bennedsen, William W Eaton, Preben Bo Mortensen

Research output: Contribution to journalArticle

Abstract

A range of complications of pregnancy, abnormal fetal growth and development, and complications of delivery have been associated with increased risk of schizophrenia. Few studies have been able to adjust for a broad range of potential confounding factors. A national population nested case-control study based on Danish longitudinal registers was conducted to investigate the risk of schizophrenia associated with exposure to a range of obstetric events. The sample included 1039 first admissions to, or contacts with Danish psychiatric services with an ICD-8 or ICD-10 diagnosis of schizophrenia and 24, 826 individually matched controls. Adjusting for the other obstetric factors, family psychiatric history, and socio-economic and demographic factors, risk of schizophrenia was associated with maternal non-attendance at antenatal appointments (Incidence Rate Ratio (IRR) 2.08, 95% CI: 1.0, 4.4), gestational age of 37 weeks or below (IRR 1.51, 95% CI: 1.0, 2.2), maternal influenza (IRR 8.2, 95% CI: 1.4, 48.8), preeclampsia (IRR 2.72, 95% CI: 1.0, 7.3), threatened premature delivery (IRR 2.39, 95% CI: 1.4, 4.1), haemorrhage during delivery (IRR 2.43, 95% CI: 1.1, 5.6), manual extraction of the baby (IRR 2.15, 95% CI: 1.1, 4.4), and maternal sepsis of childbirth and the puerperium (IRR 2.91, 95% CI: 1.1, 7.9). There was no significant interaction between the obstetric factors and either sex or family psychiatric history. The data suggest a modest association between prematurity, indicators of hypoxia, maternal infections, and maternal behaviours and risk of the later development of schizophrenia after adjusting for a number of possible confounding factors.

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalSchizophrenia Research
Volume97
Issue number1-3
DOIs
StatePublished - Dec 2007

Fingerprint

Obstetrics
Schizophrenia
Incidence
Mothers
Psychiatry
Fetal Development
Sex Factors
Maternal Behavior
Pregnancy Complications
International Classification of Diseases
Pre-Eclampsia
Growth and Development
Postpartum Period
Human Influenza
Gestational Age
Case-Control Studies
Sepsis
Appointments and Schedules
Economics
Demography

Keywords

  • Nested case-control studies
  • Obstetric complications
  • Risk factors
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Obstetric conditions and risk of first admission with schizophrenia : A Danish national register based study. / Byrne, Majella; Agerbo, Esben; Bennedsen, Birgit; Eaton, William W; Mortensen, Preben Bo.

In: Schizophrenia Research, Vol. 97, No. 1-3, 12.2007, p. 51-59.

Research output: Contribution to journalArticle

Byrne, Majella ; Agerbo, Esben ; Bennedsen, Birgit ; Eaton, William W ; Mortensen, Preben Bo. / Obstetric conditions and risk of first admission with schizophrenia : A Danish national register based study. In: Schizophrenia Research. 2007 ; Vol. 97, No. 1-3. pp. 51-59.
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