Abstract
Background To determine possible dimensions that underlie obsessive-compulsive personality disorder (OCPD) and to investigate their clinical correlates, familiality, and genetic linkage. Methods Participants were selected from 844 adults assessed with the Structured Instrument for the Diagnosis of DSM-IV Personality Disorders (SIDP) in the OCD Collaborative Genetics Study (OCGS) that targeted families with obsessive-compulsive disorder (OCD) affected sibling pairs. We conducted an exploratory factor analysis, which included the eight SIDP-derived DSM-IV OCPD traits and the indecision trait from the DSM-III, assessed clinical correlates, and estimated sib-sib correlations to evaluate familiality of the factors. Using MERLIN and MINX, we performed genome-wide quantitative trait locus (QTL) linkage analysis to test for allele sharing among individuals. Results Two factors were identified: Factor 1: order/control (perfectionism, excessive devotion to work, overconscientiousness, reluctance to delegate, and rigidity); and Factor 2: hoarding/indecision (inability to discard and indecisiveness). Factor 1 score was associated with poor insight, whereas Factor 2 score was associated with task incompletion. A significant sib-sib correlation was found for Factor 2 (rICC =.354, P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 128-135 |
| Number of pages | 8 |
| Journal | Depression and Anxiety |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- assessment and diagnosis
- genetic
- hoarding
- obsessive-compulsive disorder
- personality disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
OBSESSIVE-COMPULSIVE PERSONALITY DISORDER : EVIDENCE for TWO DIMENSIONS. / Riddle, Mark A; Maher, Brion; Wang, Ying; Grados, Marco; Bienvenu, Oscar J; Goes, Fernando S; Cullen, Bernadette; Murphy, Dennis L.; Rauch, Scott L.; Greenberg, Benjamin D.; Knowles, James A.; McCracken, James T.; Pinto, Anthony; Piacentini, John; Pauls, David L.; Rasmussen, Steven A.; Shugart, Yin Yao; Nestadt, Gerald; Samuels, Jack.
In: Depression and Anxiety, Vol. 33, No. 2, 01.02.2016, p. 128-135.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - OBSESSIVE-COMPULSIVE PERSONALITY DISORDER
T2 - EVIDENCE for TWO DIMENSIONS
AU - Riddle, Mark A
AU - Maher, Brion
AU - Wang, Ying
AU - Grados, Marco
AU - Bienvenu, Oscar J
AU - Goes, Fernando S
AU - Cullen, Bernadette
AU - Murphy, Dennis L.
AU - Rauch, Scott L.
AU - Greenberg, Benjamin D.
AU - Knowles, James A.
AU - McCracken, James T.
AU - Pinto, Anthony
AU - Piacentini, John
AU - Pauls, David L.
AU - Rasmussen, Steven A.
AU - Shugart, Yin Yao
AU - Nestadt, Gerald
AU - Samuels, Jack
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background To determine possible dimensions that underlie obsessive-compulsive personality disorder (OCPD) and to investigate their clinical correlates, familiality, and genetic linkage. Methods Participants were selected from 844 adults assessed with the Structured Instrument for the Diagnosis of DSM-IV Personality Disorders (SIDP) in the OCD Collaborative Genetics Study (OCGS) that targeted families with obsessive-compulsive disorder (OCD) affected sibling pairs. We conducted an exploratory factor analysis, which included the eight SIDP-derived DSM-IV OCPD traits and the indecision trait from the DSM-III, assessed clinical correlates, and estimated sib-sib correlations to evaluate familiality of the factors. Using MERLIN and MINX, we performed genome-wide quantitative trait locus (QTL) linkage analysis to test for allele sharing among individuals. Results Two factors were identified: Factor 1: order/control (perfectionism, excessive devotion to work, overconscientiousness, reluctance to delegate, and rigidity); and Factor 2: hoarding/indecision (inability to discard and indecisiveness). Factor 1 score was associated with poor insight, whereas Factor 2 score was associated with task incompletion. A significant sib-sib correlation was found for Factor 2 (rICC =.354, P
AB - Background To determine possible dimensions that underlie obsessive-compulsive personality disorder (OCPD) and to investigate their clinical correlates, familiality, and genetic linkage. Methods Participants were selected from 844 adults assessed with the Structured Instrument for the Diagnosis of DSM-IV Personality Disorders (SIDP) in the OCD Collaborative Genetics Study (OCGS) that targeted families with obsessive-compulsive disorder (OCD) affected sibling pairs. We conducted an exploratory factor analysis, which included the eight SIDP-derived DSM-IV OCPD traits and the indecision trait from the DSM-III, assessed clinical correlates, and estimated sib-sib correlations to evaluate familiality of the factors. Using MERLIN and MINX, we performed genome-wide quantitative trait locus (QTL) linkage analysis to test for allele sharing among individuals. Results Two factors were identified: Factor 1: order/control (perfectionism, excessive devotion to work, overconscientiousness, reluctance to delegate, and rigidity); and Factor 2: hoarding/indecision (inability to discard and indecisiveness). Factor 1 score was associated with poor insight, whereas Factor 2 score was associated with task incompletion. A significant sib-sib correlation was found for Factor 2 (rICC =.354, P
KW - assessment and diagnosis
KW - genetic
KW - hoarding
KW - obsessive-compulsive disorder
KW - personality disorder
UR - http://www.scopus.com/inward/record.url?scp=84957430408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957430408&partnerID=8YFLogxK
U2 - 10.1002/da.22452
DO - 10.1002/da.22452
M3 - Article
C2 - 26594839
AN - SCOPUS:84957430408
VL - 33
SP - 128
EP - 135
JO - Depression and Anxiety
JF - Depression and Anxiety
SN - 1091-4269
IS - 2
ER -