OBSESSIVE-COMPULSIVE PERSONALITY DISORDER

EVIDENCE for TWO DIMENSIONS

Mark A Riddle, Brion Maher, Ying Wang, Marco Grados, Oscar J Bienvenu, Fernando S Goes, Bernadette Cullen, Dennis L. Murphy, Scott L. Rauch, Benjamin D. Greenberg, James A. Knowles, James T. McCracken, Anthony Pinto, John Piacentini, David L. Pauls, Steven A. Rasmussen, Yin Yao Shugart, Gerald Nestadt, Jack Samuels

Research output: Contribution to journalArticle

Abstract

Background To determine possible dimensions that underlie obsessive-compulsive personality disorder (OCPD) and to investigate their clinical correlates, familiality, and genetic linkage. Methods Participants were selected from 844 adults assessed with the Structured Instrument for the Diagnosis of DSM-IV Personality Disorders (SIDP) in the OCD Collaborative Genetics Study (OCGS) that targeted families with obsessive-compulsive disorder (OCD) affected sibling pairs. We conducted an exploratory factor analysis, which included the eight SIDP-derived DSM-IV OCPD traits and the indecision trait from the DSM-III, assessed clinical correlates, and estimated sib-sib correlations to evaluate familiality of the factors. Using MERLIN and MINX, we performed genome-wide quantitative trait locus (QTL) linkage analysis to test for allele sharing among individuals. Results Two factors were identified: Factor 1: order/control (perfectionism, excessive devotion to work, overconscientiousness, reluctance to delegate, and rigidity); and Factor 2: hoarding/indecision (inability to discard and indecisiveness). Factor 1 score was associated with poor insight, whereas Factor 2 score was associated with task incompletion. A significant sib-sib correlation was found for Factor 2 (rICC =.354, P

Original languageEnglish (US)
Pages (from-to)128-135
Number of pages8
JournalDepression and Anxiety
Volume33
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Genetic Linkage
Quantitative Trait Loci
Personality Disorders
Statistical Factor Analysis
Alleles
Genome

Keywords

  • assessment and diagnosis
  • genetic
  • hoarding
  • obsessive-compulsive disorder
  • personality disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

OBSESSIVE-COMPULSIVE PERSONALITY DISORDER : EVIDENCE for TWO DIMENSIONS. / Riddle, Mark A; Maher, Brion; Wang, Ying; Grados, Marco; Bienvenu, Oscar J; Goes, Fernando S; Cullen, Bernadette; Murphy, Dennis L.; Rauch, Scott L.; Greenberg, Benjamin D.; Knowles, James A.; McCracken, James T.; Pinto, Anthony; Piacentini, John; Pauls, David L.; Rasmussen, Steven A.; Shugart, Yin Yao; Nestadt, Gerald; Samuels, Jack.

In: Depression and Anxiety, Vol. 33, No. 2, 01.02.2016, p. 128-135.

Research output: Contribution to journalArticle

Riddle, MA, Maher, B, Wang, Y, Grados, M, Bienvenu, OJ, Goes, FS, Cullen, B, Murphy, DL, Rauch, SL, Greenberg, BD, Knowles, JA, McCracken, JT, Pinto, A, Piacentini, J, Pauls, DL, Rasmussen, SA, Shugart, YY, Nestadt, G & Samuels, J 2016, 'OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE for TWO DIMENSIONS', Depression and Anxiety, vol. 33, no. 2, pp. 128-135. https://doi.org/10.1002/da.22452
Riddle, Mark A ; Maher, Brion ; Wang, Ying ; Grados, Marco ; Bienvenu, Oscar J ; Goes, Fernando S ; Cullen, Bernadette ; Murphy, Dennis L. ; Rauch, Scott L. ; Greenberg, Benjamin D. ; Knowles, James A. ; McCracken, James T. ; Pinto, Anthony ; Piacentini, John ; Pauls, David L. ; Rasmussen, Steven A. ; Shugart, Yin Yao ; Nestadt, Gerald ; Samuels, Jack. / OBSESSIVE-COMPULSIVE PERSONALITY DISORDER : EVIDENCE for TWO DIMENSIONS. In: Depression and Anxiety. 2016 ; Vol. 33, No. 2. pp. 128-135.
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