Observations regarding eschenmoser sulfide contractions of β-oxygenated thiolactams

David S. Hart, Li Qiang Sun, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

Application of an Eschenmoser sulfide contraction to a thiolactam bearing a β-acyloxy group was complicated by a competitive β-elimination reaction. Changing the β-substituent to an alkoxy group retarded the rate of elimination such that sulfide contraction products could be obtained.

Original languageEnglish (US)
Pages (from-to)7787-7790
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number43
DOIs
StatePublished - Oct 23 1995

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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