Observational study of subclinical diabetic macular edema

Michael J. Elman, Michelle D. Sloan, Jo Ann Starr, Theresa M. Butcher, Pamela V. Singletary, Nancy Gore, Teresa Coffey, Giorya Andreani, Peter Sotirakos, Terri Cain, George S. Sharuk, Paul G. Arrigg, Deborah K. Schlossman, Timothy J. Murtha, Jennifer K. Sun, Sabera T. Shah, Margaret E. Stockman, Ann Kopple, Robert W. Cavicchi, Thomas W. StoneJohn W. Kitchens, William J. Wood, Michelle Buck, Jeanne Van Arsdall, Judith L. Cruz, Edward A. Slade, Stephen T. Blevins, David Browning, Andrew N. Antoszyk, Danielle R. Brooks, Jennifer V. Helms, Angela K. Price, Melissa K. Cowen, Angella S. Karow, Heather L. Murphy, Michael D. McOwen, Linda M. Davis, Loraine M. Clark, Uma M. Balasubramaniam, Donna McClain, Michele E. Powers, Jon M. Braverman, Antonio P. Ciardella, Leif S. Ryman, Sasha I. Montalvo, Janelle Dane Zapata, Rosemary C. Rhodes, Debbie M. Brown, Alice T. Lyon, Manjot K. Gill, Lori A. Kaminski, Lori E. Ackatz, Laima M. O'Donnell, Jonathan Shankle, Dawn M. Ryan, Scott M. Friedman, Kelly A. Blackmer, Jolleen S. Key, Karen Sjoblom, Damanda A. Fagan, Steve Carlton, Allen McKinney, Magdalena G. Krzystolik, Mary B. Savell, Sandra Henriques, Joanne E. Bache, Jeffrey G. Gross, Amy M. Flowers, Heidi K. Lovit, Randall L. Price, James L. Kinyoun, Susan A. Rath, Brad C. Clifton, James D. Leslie, Paul M. Beer, Denise Garza, Eugenia Olmeda, Charisse Whitney, Joe Fischer, Sharon D. Solomon, Susan Bressler, Mary Frey, Sandra West, Deborah Donohue, Janis Graul, David Emmert, Paul Andrew Edwards, Sheila M. Rock, Janet Murphy, Brian A. Rusinek, Tracy A. Troszak, Garvin H. Davis, Helen K. Li, Happy Spillar, John M. Bourg, Amber Crocker, Craig N. Kelso, Howard L. Cummings, Deanna Jo Long, Stacy Carpenter, Julie P. Berry, Joseph M. Googe, Christina T. Higdon, Cecile Hunt, Paul A. Blais, Judy E. Kim, Dennis P. Han, William J. Wirostko, Dawn Alvarez, Jeanette Graf, Judy Flanders, Joseph R. Beringer, Dennis B. Backes, Clement K. Chan, Kimberly S. Walther, Sandra U. Castillo, Kenneth M. Huff, Donna J. Chesbrough, Caldwell W. Smith, Robert H. Janigian, Harold A. Woodcome, Collin L. DuCoty, Sylvia Varadian, Erika Banalewicz, Mark Hamel, Alex L. Nagle, N. M. Bressler, K. M. Miller, R. W. Beck, S. B. Bressler, A. R. Glassman, M. Melia

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the rate of progression of eyes with subclinical diabetic macular edema (DME) to clinically apparent DME or DME necessitating treatment during a 2-year period. Methods: In all, 43 eyes from 39 study participants with subclinical DME, defined as absence of foveal center edema as determined with slit lamp biomicroscopy but a center point thickness (CPT) between 225 and 299 μm on time domain (Stratus, Carl Zeiss Meditec) optical coherence tomography (OCT) scan, were enrolled from 891 eyes of 582 subjects screened. Eyes were evaluated annually for up to 2 years for the primary outcome, which was an increase in OCT CPT of at least 50 μm from baseline and a CPT of at least 300 μm, or treatment for DME (performed at the discretion of the investigator). Results: The cumulative probability of meeting an increase in OCT CPT of at least 50 μm from baseline and a CPT of at least 300 μm, or treatment for DME was 27% (95% confidence interval (CI): 14%, 38%) by 1 year and 38% (95% CI: 23%, 50%) by 2 years. Conclusions: Although subclinical DME may be uncommon, this study suggests that between approximately one-quarter and one-half of eyes with subclinical DME will progress to more definite thickening or be judged to need treatment for DME within 2 years after its identification.

Original languageEnglish (US)
Pages (from-to)833-840
Number of pages8
JournalEye (Basingstoke)
Volume26
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • diabetic macular edema
  • optical coherence tomography
  • subclinical diabetic macular edema

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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  • Cite this

    Elman, M. J., Sloan, M. D., Starr, J. A., Butcher, T. M., Singletary, P. V., Gore, N., Coffey, T., Andreani, G., Sotirakos, P., Cain, T., Sharuk, G. S., Arrigg, P. G., Schlossman, D. K., Murtha, T. J., Sun, J. K., Shah, S. T., Stockman, M. E., Kopple, A., Cavicchi, R. W., ... Melia, M. (2012). Observational study of subclinical diabetic macular edema. Eye (Basingstoke), 26(6), 833-840. https://doi.org/10.1038/eye.2012.53