Observational Study of Need for Thrombolytic Therapy and Incidence of Bacteremia using Taurolidine-Citrate-Heparin, Taurolidine-Citrate and Heparin Catheter Locks in Patients Treated with Hemodialysis

Laurie R. Solomon, John S. Cheesbrough, Ramya Bhargava, Nicos Mitsides, Michael Heap, Gerwyn Green, Peter Diggle

Research output: Contribution to journalArticle

Abstract

Catheter-related blood stream infections may be reduced by interdialytic locking with Taurolidine, a nontoxic antimicrobial agent. A formulation of 1.35% Taurolidine in 4% citrate (TC) is associated with a greater need for thrombolysis to maintain catheter patency than 5000U/ml heparin. Our aim was to determine whether addition of 500Units/ml of heparin to TC reduces the need for thrombolysis. TCH (1.35% taurolidine, 4% citrate and 500U/ml heparin) was compared to TC and Heparin 5000U/ml using retrospective data. Hundred and six adult hemodialysis patients with internal jugular tunnelled intravascular catheters using TCH were compared with 34 patients using TC and 34 patients using heparin 5000U/ml respectively. Outcomes were time to first use of thrombolysis and bacteremia rates.TCH reduced the need for thrombolysis compared to TC (hazard ratio, 0.2; 95%CI: 0.06, 0.5; p

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalSeminars in Dialysis
Volume25
Issue number2
DOIs
StatePublished - Mar 2012
Externally publishedYes

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Thrombolytic Therapy
Bacteremia
Citric Acid
Observational Studies
Renal Dialysis
Heparin
Catheters
Incidence
Anti-Infective Agents
taurolidine
Neck
Infection

ASJC Scopus subject areas

  • Nephrology

Cite this

Observational Study of Need for Thrombolytic Therapy and Incidence of Bacteremia using Taurolidine-Citrate-Heparin, Taurolidine-Citrate and Heparin Catheter Locks in Patients Treated with Hemodialysis. / Solomon, Laurie R.; Cheesbrough, John S.; Bhargava, Ramya; Mitsides, Nicos; Heap, Michael; Green, Gerwyn; Diggle, Peter.

In: Seminars in Dialysis, Vol. 25, No. 2, 03.2012, p. 233-238.

Research output: Contribution to journalArticle

Solomon, Laurie R. ; Cheesbrough, John S. ; Bhargava, Ramya ; Mitsides, Nicos ; Heap, Michael ; Green, Gerwyn ; Diggle, Peter. / Observational Study of Need for Thrombolytic Therapy and Incidence of Bacteremia using Taurolidine-Citrate-Heparin, Taurolidine-Citrate and Heparin Catheter Locks in Patients Treated with Hemodialysis. In: Seminars in Dialysis. 2012 ; Vol. 25, No. 2. pp. 233-238.
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