Abstract
The tositumomab/131I-tositumomab radioimmunotherapy regimen is administered as a dosimetric dose followed by a therapeutic dose. The biodistribution of the dosimetric dose is assessed by quantitative calculations of whole-body residence time (TBRT) and visual examination of whole-body γ-camera images, to determine the administered radioactivity dose and whether a therapeutic dose can be administered. We investigated whether altered biodistribution of 131I-tositumomab could be identified using quantitative TBRT. Methods: BioClinica, Inc., provided γ-camera images to an independent reviewer to assess altered 131I-tositumomab biodistribution in patients reported to a registry. Results: Of 2,649 therapeutic doses, 5 (0.2%) were cancelled because of altered biodistribution as determined by γ-camera images and TBRT. Of these, 3 γ-camera images were assessed by the independent reviewer; one showed altered biodistribution (0.04%) and was in agreement with the TBRT on-site calculation. Conclusion: TBRT alone should be used to determine altered biodistribution and hence whether to administer the therapeutic dose.
Original language | English (US) |
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Pages (from-to) | 1800-1803 |
Number of pages | 4 |
Journal | Journal of Nuclear Medicine |
Volume | 56 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2015 |
Keywords
- Altered biodistribution
- Therapeutic dose
- Tositumomab
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging