TY - JOUR
T1 - Obligatory role for the immediate early gene NARP in critical period plasticity
AU - Gu, Yu
AU - Huang, Shiyong
AU - Chang, Michael C.
AU - Worley, Paul
AU - Kirkwood, Alfredo
AU - Quinlan, Elizabeth M.
N1 - Funding Information:
This work was supported by NIH grants R01EY016431 (to E.M.Q.) and R01EY012124 (to A.K.).
PY - 2013/7/24
Y1 - 2013/7/24
N2 - The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding protein that is specifically enriched at excitatory synapses onto fast-spiking parvalbumin-positive interneurons (FS [PV] INs). Here, we show that transgenic deletion of NARP decreases the number of excitatory synaptic inputs onto FS (PV) INs and reduces net excitatory synaptic drive onto FS (PV) INs. Accordingly, the visual cortex of NARP-/- mice is hyperexcitable and unable to express ocular dominance plasticity, although many aspects of visual function are unimpaired. Importantly, the number and strength of inhibitory synaptic contacts from FS (PV) INs onto principle neurons in the visual cortex is normal in NARP-/- mice, and enhancement of thisoutput recovers the expression of experience-dependent synaptic plasticity. Thus the recruitment of inhibition from FS (PV) INs plays a central role in enabling the critical period for ocular dominance plasticity
AB - The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding protein that is specifically enriched at excitatory synapses onto fast-spiking parvalbumin-positive interneurons (FS [PV] INs). Here, we show that transgenic deletion of NARP decreases the number of excitatory synaptic inputs onto FS (PV) INs and reduces net excitatory synaptic drive onto FS (PV) INs. Accordingly, the visual cortex of NARP-/- mice is hyperexcitable and unable to express ocular dominance plasticity, although many aspects of visual function are unimpaired. Importantly, the number and strength of inhibitory synaptic contacts from FS (PV) INs onto principle neurons in the visual cortex is normal in NARP-/- mice, and enhancement of thisoutput recovers the expression of experience-dependent synaptic plasticity. Thus the recruitment of inhibition from FS (PV) INs plays a central role in enabling the critical period for ocular dominance plasticity
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U2 - 10.1016/j.neuron.2013.05.016
DO - 10.1016/j.neuron.2013.05.016
M3 - Article
C2 - 23889936
AN - SCOPUS:84880688018
SN - 0896-6273
VL - 79
SP - 335
EP - 346
JO - Neuron
JF - Neuron
IS - 2
ER -