Objective Evaluation of Motor Symptoms in Parkinson's Disease via a Dual System of LEAP Motion Controllers

Elizaveta Naydanova, Min Jae Kim, Brian Y. Hwang, Kelly A. Mills, William S. Anderson, Yousef Salimpour

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Parkinson's Disease (PD) is a common neurodegenerative disorder clinically characterized by neuromotor symptoms of tremor, rigidity, and bradykinesia. Existing quantification methods of PD-related symptoms are largely subjective and rater-dependent, warranting the development of objective device-based assessments. This study introduces a sensitive computerized system of two LEAP Motion Controllers (LMCs) that can be used to quantify neuromotor symptoms in PD patients. The accuracy of the system was evaluated using a series of clinically relevant hand motion tasks, which included finger tapping, hand movements, and pronation/supination. By capturing hand motion from multiple angles, the dual system of LMCs recognizes a broader range of hand positions, therefore increasing data specificity as well as preventing data loss due to line-of-sight obstructions. The use of multi-threading contributed to a high sampling rate of 60 Hz, which allows a complete reconstruction of high-frequency signals essential for recognizing the fast motions associated with postural tremor. Finally, to make the application of the dual system more easily accessible to both patients and clinicians, we developed a GUI and 3D data visualization kit. The dual system of LMCs, which is characterized by precision, objectivity, and ease of use, can become a useful supplement in intraoperative and clinical testing and treatment of PD.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE 20th International Conference on Bioinformatics and Bioengineering, BIBE 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages826-829
Number of pages4
ISBN (Electronic)9781728195742
DOIs
StatePublished - Oct 2020
Event20th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2020 - Virtual, Cincinnati, United States
Duration: Oct 26 2020Oct 28 2020

Publication series

NameProceedings - IEEE 20th International Conference on Bioinformatics and Bioengineering, BIBE 2020

Conference

Conference20th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2020
CountryUnited States
CityVirtual, Cincinnati
Period10/26/2010/28/20

Keywords

  • LEAP Motion Controllers
  • Motion detection
  • Objective quantification
  • Parkinson's Disease
  • Symptoms

ASJC Scopus subject areas

  • Biotechnology
  • Genetics
  • Molecular Biology
  • Artificial Intelligence
  • Computer Science Applications
  • Biomedical Engineering
  • Modeling and Simulation
  • Health Informatics

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