Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography

Romain Bocheux, Bathilde Rivière, Pascal Pernot, Cristina Georgeon, Vincent Borderie, Kristina Irsch, Karsten Plamann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lack of corneal transparency is a major cause of blindness worldwide. However, means to assess corneal transparency are limited and in current clinical and eye-bank practice usually involve a subjective and qualitative observation of opacities, sometimes with comparison against an arbitrary grading scale, by means of slit-lamp biomicroscopy. To address this unmet need, we have developed a method for corneal transparency assessment based on a new optical data analysis-based approach. Our method allows the objective extraction of quantitative parameters (including the scattering mean-free path, ls, a major indicator of scattering extent and thus of transparency of a medium) based on a physical model of corneal transparency and has been validated by laboratory experiments, using high-resolution, ex-vivo "fullfield" optical coherence tomography (FF-OCT). Here, we apply our algorithm to depth-resolved spectral domain OCT (SD-OCT) images of in-vivo corneas and demonstrate the feasibility of our approach by means of four representative clinical cases. Specifically, we illustrate its potential in discriminating between the four clinical cases and, if applicable, deriving the scattering mean-free path as a quantitative measure of corneal transparency from objective analysis of stromal light backscattering (attenuation of the coherent mean) with SD-OCT. This measure may be related to, or expressed as, Strehl ratio reduction and thus retinal PSF broadening. As such, our approach not only has the potential to supply the demand for an objective means to quantify corneal transparency in the clinical setting, but also to create an association with visual function.

Original languageEnglish (US)
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
PublisherSPIE
ISBN (Electronic)9781510628397
DOIs
StatePublished - Jan 1 2019
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: Jun 23 2019Jun 25 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11073
ISSN (Print)1605-7422

Conference

ConferenceClinical and Preclinical Optical Diagnostics II 2019
CountryGermany
CityMunich
Period6/23/196/25/19

Fingerprint

Optical tomography
Optical Coherence Tomography
Transparency
quantitative analysis
tomography
Eye Banks
mean free path
Blindness
Chemical analysis
scattering
blindness
Cornea
cornea
Observation
opacity
Light
Scattering
luminaires
slits
backscattering

Keywords

  • Corneal transparency
  • In vivo
  • Light scattering
  • Objective
  • OCT
  • Quantitative

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Bocheux, R., Rivière, B., Pernot, P., Georgeon, C., Borderie, V., Irsch, K., & Plamann, K. (2019). Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography. In J. Q. Brown, & T. G. van Leeuwen (Eds.), Clinical and Preclinical Optical Diagnostics II [1107318] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073). SPIE. https://doi.org/10.1117/12.2527085

Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography. / Bocheux, Romain; Rivière, Bathilde; Pernot, Pascal; Georgeon, Cristina; Borderie, Vincent; Irsch, Kristina; Plamann, Karsten.

Clinical and Preclinical Optical Diagnostics II. ed. / J. Quincy Brown; Ton G. van Leeuwen. SPIE, 2019. 1107318 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11073).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bocheux, R, Rivière, B, Pernot, P, Georgeon, C, Borderie, V, Irsch, K & Plamann, K 2019, Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography. in JQ Brown & TG van Leeuwen (eds), Clinical and Preclinical Optical Diagnostics II., 1107318, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11073, SPIE, Clinical and Preclinical Optical Diagnostics II 2019, Munich, Germany, 6/23/19. https://doi.org/10.1117/12.2527085
Bocheux R, Rivière B, Pernot P, Georgeon C, Borderie V, Irsch K et al. Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography. In Brown JQ, van Leeuwen TG, editors, Clinical and Preclinical Optical Diagnostics II. SPIE. 2019. 1107318. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2527085
Bocheux, Romain ; Rivière, Bathilde ; Pernot, Pascal ; Georgeon, Cristina ; Borderie, Vincent ; Irsch, Kristina ; Plamann, Karsten. / Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography. Clinical and Preclinical Optical Diagnostics II. editor / J. Quincy Brown ; Ton G. van Leeuwen. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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