Obesity as a consequence of undernutrition

Research output: Contribution to journalArticle

Abstract

The role of early undernutrition as a risk factor for adult obesity is supported by data from epidemiologic, clinical, and animal studies. In experimental animals, maternal energy restriction results in pups of reduced body size but with increased fat depots and hyperphagia. Similarly, reduced lean mass with relative increase in fat mass in the newborn have been described in gestational energy restriction in human populations. When coupled with the appropriate environmental conditions (widely available energy-dense foods, low energy expenditure) those factors predispose a person to excess weight gain and body fat accumulation in adult life. This combination of early biologic factors with environmental factors is best exemplified in the situation of populations from developing countries undergoing economic and nutritional transition, where high prevalence of low birth weight now is combined with an urban, sedentary lifestyle and increased access to low-cost, energy-dense foods. Thus reducing the prevalence of intrauterine growth retardation and early undernutrition should be an important component of our effort to control the worldwide obesity epidemic.

Original languageEnglish (US)
JournalJournal of Pediatrics
Volume149
Issue number3 SUPPL.
DOIs
StatePublished - Sep 2006

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Malnutrition
Obesity
Fats
Sedentary Lifestyle
Food
Hyperphagia
Fetal Growth Retardation
Biological Factors
Low Birth Weight Infant
Body Size
Energy Metabolism
Population
Developing Countries
Weight Gain
Adipose Tissue
Economics
Mothers
Newborn Infant
Costs and Cost Analysis
Clinical Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Obesity as a consequence of undernutrition. / Caballero, Benjamin H.

In: Journal of Pediatrics, Vol. 149, No. 3 SUPPL., 09.2006.

Research output: Contribution to journalArticle

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