Obesity and metabolic phenotypes (metabolically healthy and unhealthy variants) are significantly associated with prevalence of elevated C-reactive protein and hepatic steatosis in a large healthy Brazilian population

Sameer Shaharyar, Lara L. Roberson, Omar Jamal, Adnan Younus, Michael Blaha, Shozab S. Ali, Kenneth Zide, Arthur A. Agatston, Roger S Blumenthal, Raquel D. Conceição, Raul D. Santos, Khurram Nasir

Research output: Contribution to journalArticle

Abstract

Background. Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes. The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities. Methods. We evaluated 5,519 healthy, Brazilian subjects (43±10 years, 78% males), free of known cardiovascular disease. Those with 2 and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound. Results. Overall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF. The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P

Original languageEnglish (US)
Article number178526
JournalJournal of Obesity
Volume2015
DOIs
StatePublished - 2015

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C-Reactive Protein
Obesity
Phenotype
Weights and Measures
Liver
Waist Circumference
Population
Healthy Volunteers
Cardiovascular Diseases
Inflammation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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Obesity and metabolic phenotypes (metabolically healthy and unhealthy variants) are significantly associated with prevalence of elevated C-reactive protein and hepatic steatosis in a large healthy Brazilian population. / Shaharyar, Sameer; Roberson, Lara L.; Jamal, Omar; Younus, Adnan; Blaha, Michael; Ali, Shozab S.; Zide, Kenneth; Agatston, Arthur A.; Blumenthal, Roger S; Conceição, Raquel D.; Santos, Raul D.; Nasir, Khurram.

In: Journal of Obesity, Vol. 2015, 178526, 2015.

Research output: Contribution to journalArticle

Shaharyar, Sameer ; Roberson, Lara L. ; Jamal, Omar ; Younus, Adnan ; Blaha, Michael ; Ali, Shozab S. ; Zide, Kenneth ; Agatston, Arthur A. ; Blumenthal, Roger S ; Conceição, Raquel D. ; Santos, Raul D. ; Nasir, Khurram. / Obesity and metabolic phenotypes (metabolically healthy and unhealthy variants) are significantly associated with prevalence of elevated C-reactive protein and hepatic steatosis in a large healthy Brazilian population. In: Journal of Obesity. 2015 ; Vol. 2015.
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abstract = "Background. Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes. The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities. Methods. We evaluated 5,519 healthy, Brazilian subjects (43±10 years, 78{\%} males), free of known cardiovascular disease. Those with 2 and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound. Results. Overall, 40{\%} of OW individuals were metabolically healthy, and 12{\%} normal-weight had ≥2 MRF. The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22{\%} versus 12{\%}, and 40{\%} versus 8{\%} respectively (P",
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AU - Shaharyar, Sameer

AU - Roberson, Lara L.

AU - Jamal, Omar

AU - Younus, Adnan

AU - Blaha, Michael

AU - Ali, Shozab S.

AU - Zide, Kenneth

AU - Agatston, Arthur A.

AU - Blumenthal, Roger S

AU - Conceição, Raquel D.

AU - Santos, Raul D.

AU - Nasir, Khurram

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AB - Background. Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes. The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities. Methods. We evaluated 5,519 healthy, Brazilian subjects (43±10 years, 78% males), free of known cardiovascular disease. Those with 2 and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound. Results. Overall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF. The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P

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