Obesity and long-term survival after radical prostatectomy

Heather J. Chalfin, Seung Bae Lee, Byong Chang Jeong, Stephen J. Freedland, Hamid Alai, Zhaoyong Feng, Bruce J. Trock, Alan W. Partin, Elizabeth Humphreys, Patrick C. Walsh, Misop Han

Research output: Contribution to journalArticlepeer-review


Purpose Obesity is a modifiable risk factor associated with worse outcomes for many cancers, yet implications for prostate cancer are not well understood. Notably the impact of body mass index on long-term survival after treatment is unclear. We performed a retrospective cohort study on a large series of men who underwent radical prostatectomy to assess the impact of obesity on long-term biochemical recurrence-free survival, prostate cancer specific survival and overall survival. Materials and Methods Between 1982 and 2012, 11,152 men underwent radical prostatectomy at a single tertiary referral center. Patients were stratified according to body mass index as normal weight (body mass index less than 25 kg/m2), overweight (body mass index 25 to less than 30 kg/m2), mild obesity (body mass index 30 to less than 35 kg/m2) and moderate/severe obesity (body mass index 35 kg/m2 or greater), comprising 27.6%, 56.0%, 14.1% and 2.3% of the cohort, respectively. Covariates included age, preoperative prostate specific antigen, surgery year, Gleason score, pathological stage, surgical margin and race. Predictors of biochemical recurrence-free survival, prostate cancer specific survival and overall survival were identified using Cox proportional hazard models. Results Median followup was 5 years (range 1 to 27). Actuarial 20-year biochemical recurrence-free survival for mild and moderate/severe obesity was 65% and 51%, respectively, compared to 76% for normal weight men (p ≤0.001). In a multivariate model obesity was a significant predictor of biochemical recurrence-free survival (mild HR 1.30, p = 0.002; moderate/severe HR 1.45, p = 0.028) and overall survival (mild HR 1.41, p = 0.003; moderate/severe HR 1.81, p = 0.033). However, only mild obesity was significantly associated with prostate cancer specific survival (HR 1.51, p = 0.040), whereas moderate/severe obesity was not (HR 1.58, p = 0.356). Conclusions Obese men have higher rates of biochemical recurrence than normal weight patients during long-term followup. Obesity at the time of surgery independently predicts overall survival and biochemical recurrence-free survival but not prostate cancer specific survival.

Original languageEnglish (US)
Pages (from-to)1100-1104
Number of pages5
JournalJournal of Urology
Issue number4
StatePublished - Oct 1 2014


  • mortality
  • obesity body mass index
  • prostatectomy
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology


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