Obesity and kidney disease: Hidden consequences of the epidemic

Csaba P. Kovesdy, Susan L. Furth, Carmine Zoccali, Philip Kam Tao Li, Guillermo Garcia-Garcia, Mohammed Benghanem-Gharbi, Rik Bollaert, Sophie Dupuis, Timur Erk, Kamyar Kalantar-Zadeh, Csaba Kovesdy, Charlotte Osafo, Miguel C. Riella, Elena Zakharova, on behalf of the World Kidney Day Steering Committee

Research output: Contribution to journalEditorial

Abstract

Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risks of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a series of complex pathophysiologic changes occur that lead to the development of Chronic Kidney Disease. These include on the one hand effects mediated by the downstream consequences of obesity (such as diabetes mellitus and hypertension), but also direct effects of adipose tissue, via humoral factors such as leptin, adiponectin, resistin and visfatin). In obese individuals a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight, leading to glomerulomegaly and accompanied by deposition of adipose tissue in the glomerulus and the gradual development of focal segmental glomerulosclerosis. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. In addition to the development of Chronic Kidney Disease, obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. Interventions to stem the tide of obesity are thus extremely important for preventing the development and progression of Chronic Kidney Disease and other disorders of the kidneys. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalJournal of Renal Care
Volume43
Issue number1
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

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Kidney Diseases
Obesity
Chronic Renal Insufficiency
Adipose Tissue
Nicotinamide Phosphoribosyltransferase
Resistin
Kidney
Focal Segmental Glomerulosclerosis
Nephrolithiasis
Kidney Neoplasms
Adiponectin
Health Policy
Leptin
Diabetes Mellitus
Body Mass Index
Cardiovascular Diseases
Body Weight
Hypertension
Education
Incidence

Keywords

  • Chronic kidney disease
  • Obesity
  • Prevention

ASJC Scopus subject areas

  • Nephrology
  • Advanced and Specialized Nursing

Cite this

Kovesdy, C. P., Furth, S. L., Zoccali, C., Li, P. K. T., Garcia-Garcia, G., Benghanem-Gharbi, M., ... on behalf of the World Kidney Day Steering Committee (2017). Obesity and kidney disease: Hidden consequences of the epidemic. Journal of Renal Care, 43(1), 3-10. https://doi.org/10.1111/jorc.12194

Obesity and kidney disease : Hidden consequences of the epidemic. / Kovesdy, Csaba P.; Furth, Susan L.; Zoccali, Carmine; Li, Philip Kam Tao; Garcia-Garcia, Guillermo; Benghanem-Gharbi, Mohammed; Bollaert, Rik; Dupuis, Sophie; Erk, Timur; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba; Osafo, Charlotte; Riella, Miguel C.; Zakharova, Elena; on behalf of the World Kidney Day Steering Committee.

In: Journal of Renal Care, Vol. 43, No. 1, 01.03.2017, p. 3-10.

Research output: Contribution to journalEditorial

Kovesdy, CP, Furth, SL, Zoccali, C, Li, PKT, Garcia-Garcia, G, Benghanem-Gharbi, M, Bollaert, R, Dupuis, S, Erk, T, Kalantar-Zadeh, K, Kovesdy, C, Osafo, C, Riella, MC, Zakharova, E & on behalf of the World Kidney Day Steering Committee 2017, 'Obesity and kidney disease: Hidden consequences of the epidemic', Journal of Renal Care, vol. 43, no. 1, pp. 3-10. https://doi.org/10.1111/jorc.12194
Kovesdy CP, Furth SL, Zoccali C, Li PKT, Garcia-Garcia G, Benghanem-Gharbi M et al. Obesity and kidney disease: Hidden consequences of the epidemic. Journal of Renal Care. 2017 Mar 1;43(1):3-10. https://doi.org/10.1111/jorc.12194
Kovesdy, Csaba P. ; Furth, Susan L. ; Zoccali, Carmine ; Li, Philip Kam Tao ; Garcia-Garcia, Guillermo ; Benghanem-Gharbi, Mohammed ; Bollaert, Rik ; Dupuis, Sophie ; Erk, Timur ; Kalantar-Zadeh, Kamyar ; Kovesdy, Csaba ; Osafo, Charlotte ; Riella, Miguel C. ; Zakharova, Elena ; on behalf of the World Kidney Day Steering Committee. / Obesity and kidney disease : Hidden consequences of the epidemic. In: Journal of Renal Care. 2017 ; Vol. 43, No. 1. pp. 3-10.
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