TY - JOUR
T1 - Obesity and cardiovascular disease risk among Africans residing in Europe and Africa
T2 - the RODAM study
AU - Commodore-Mensah, Y.
AU - Agyemang, C.
AU - Aboagye, J. A.
AU - Echouffo-Tcheugui, J. B.
AU - Beune, E.
AU - Smeeth, L.
AU - Klipstein-Grobusch, K.
AU - Danquah, I.
AU - Schulze, M.
AU - Boateng, D.
AU - Meeks, K. A.C.
AU - Bahendeka, S.
AU - Ahima, R. S.
N1 - Funding Information:
The RODAM study was supported by the European Commissionunder the Framework Program Grant Number: 278901. YCM was supported by a career development grant awarded to the Johns Hopkins Institute for Clinical and Translational Research 5KL2TR001077–05. “KACM is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health CRGGH. The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health1ZIAHG200362.” RSA is supported by a Bloomberg Distinguished Professorship at Johns Hopkins University.
Funding Information:
The RODAM study was supported by the European Commission under the Framework Program Grant Number: 278901. YCM was supported by a career development grant awarded to the Johns Hopkins Institute for Clinical and Translational Research 5KL2TR001077–05. “KACM is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health CRGGH. The CRGGH is supported by the N ational Human Genome Research Institute , the N ational Institute of Diabetes and Digestive and Kidney Diseases , the C enter for Information Technology, and the Office of the Director at the N ational Institutes of Health 1ZIAHG200362. ” RSA is supported by a Bloomberg Distinguished Professorship at J ohns Hopkins University .
Publisher Copyright:
© 2020 Asia Oceania Association for the Study of Obesity
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Background: The association between anthropometric variables and cardiovascular disease (CVD) risk among Africans is unclear. We examined the discriminative ability of anthropometric variables and estimate cutoffs for predicting CVD risk among Africans. Methods: The Research on Obesity and Diabetes among African Migrants (RODAM) study was a multisite cross-sectional study of Africans in Ghana and Europe. We calculated AHA/ACC Pooled Cohort Equations (PCE) scores for 3661 participants to ascertain CVD risk, and compared a body shape index (ABSI), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), Relative Fat Mass (RFM), and Waist to Height Ratio (WHtR). Logistic regression and receiver operating curve analyses were performed to derive cutoffs for identifying high predicted CVD risk (PCE score ≥7.5%). Results: Among men, WC (adjusted Odds Ratio (aOR): 2.25, 95% CI; 1:50–3:37) was strongly associated with CVD risk. Among women, WC (aOR: 1.69, 95% CI: 1:33–2:14) also displayed the strongest association with CVD risk in the BMI-adjusted model but WHR displayed the strongest fit. All variables were superior discriminators of high CVD risk in men (c-statistic range: 0.887–0.891) than women (c-statistic range: 0.677–0.707). The optimal WC cutoff for identifying participants at high CVD risk was 89 cm among men and identified the most cases (64%). Among women, the recommended WC cutoff of 94 cm or WHR cutoff of 0.90 identified the most cases (92%). Conclusions: Anthropometric variables were stronger discriminators of high CVD risk in African men than women. Greater WC was associated with high CVD risk in men while WHR and WC were associated with high CVD risk in women.
AB - Background: The association between anthropometric variables and cardiovascular disease (CVD) risk among Africans is unclear. We examined the discriminative ability of anthropometric variables and estimate cutoffs for predicting CVD risk among Africans. Methods: The Research on Obesity and Diabetes among African Migrants (RODAM) study was a multisite cross-sectional study of Africans in Ghana and Europe. We calculated AHA/ACC Pooled Cohort Equations (PCE) scores for 3661 participants to ascertain CVD risk, and compared a body shape index (ABSI), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), Relative Fat Mass (RFM), and Waist to Height Ratio (WHtR). Logistic regression and receiver operating curve analyses were performed to derive cutoffs for identifying high predicted CVD risk (PCE score ≥7.5%). Results: Among men, WC (adjusted Odds Ratio (aOR): 2.25, 95% CI; 1:50–3:37) was strongly associated with CVD risk. Among women, WC (aOR: 1.69, 95% CI: 1:33–2:14) also displayed the strongest association with CVD risk in the BMI-adjusted model but WHR displayed the strongest fit. All variables were superior discriminators of high CVD risk in men (c-statistic range: 0.887–0.891) than women (c-statistic range: 0.677–0.707). The optimal WC cutoff for identifying participants at high CVD risk was 89 cm among men and identified the most cases (64%). Among women, the recommended WC cutoff of 94 cm or WHR cutoff of 0.90 identified the most cases (92%). Conclusions: Anthropometric variables were stronger discriminators of high CVD risk in African men than women. Greater WC was associated with high CVD risk in men while WHR and WC were associated with high CVD risk in women.
KW - Adiposity
KW - Cardiovascular diseases
KW - Emigrants and immigrants
KW - Ethnic groups
KW - Obesity
KW - Risk factors
KW - Sub-Saharan Africa
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U2 - 10.1016/j.orcp.2020.01.007
DO - 10.1016/j.orcp.2020.01.007
M3 - Article
C2 - 32061582
AN - SCOPUS:85079382055
SN - 1871-403X
VL - 14
SP - 151
EP - 157
JO - Obesity Research and Clinical Practice
JF - Obesity Research and Clinical Practice
IS - 2
ER -