Obesity and cancer: The role of dysfunctional adipose tissue

Rob C.M. Van Kruijsdijk; Elsken Van Der Wall; Frank L.J. Visseren

doi:10.1158/1055-9965.EPI-09-0372

Obesity and cancer: The role of dysfunctional adipose tissue

Rob C.M. Van Kruijsdijk, Elsken Van Der Wall, Frank L.J. Visseren

School of Medicine

Research output: Contribution to journal › Review article

Abstract

Overweight and obesity are health problems of epidemic proportions, increasing the risk not only of cardiovascular disease and type 2 diabetes mellitus but also of various types of cancer. Obesity is strongly associated with changes in the physiological function of adipose tissue, leading to insulin resistance, chronic inflammation, and altered secretion of adipokines. Several of these factors, such as insulin resistance, increased levels of leptin, plasminogen activator inhibitor-1, and endogenous sex steroids, decreased levels of adiponectin, and chronic inflammation, are involved in carcinogenesis and cancer progression. This article reviews these mechanisms, focusing on adipose tissue dysfunction as a unifying causal factor. Although understanding of the link between obesity and cancer might provide therapeutic targets, preventing overweight and obesity still remains number one priority.

Original language	English (US)
Pages (from-to)	2569-2578
Number of pages	10
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	18
Issue number	10
DOIs	https://doi.org/10.1158/1055-9965.EPI-09-0372
State	Published - Oct 1 2009

ASJC Scopus subject areas

Epidemiology
Oncology

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Van Kruijsdijk, R. C. M., Van Der Wall, E., & Visseren, F. L. J. (2009). Obesity and cancer: The role of dysfunctional adipose tissue. Cancer Epidemiology Biomarkers and Prevention, 18(10), 2569-2578. https://doi.org/10.1158/1055-9965.EPI-09-0372

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