Obesity and albuminuria among adults with type 2 diabetes: The look AHEAD (Action for Health in Diabetes) Study

Holly Kramer; David Reboussin; Alain G. Bertoni; Santica Marcovina; Edward Lipkin; Frank L. Greenway; Frederick L. Brancati

doi:10.2337/dc08-2059

Obesity and albuminuria among adults with type 2 diabetes: The look AHEAD (Action for Health in Diabetes) Study

Holly Kramer, David Reboussin, Alain G. Bertoni, Santica Marcovina, Edward Lipkin, Frank L. Greenway, Frederick L. Brancati

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

OBJECTIVE - To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS - In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates. RESULTS - The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model. CONCLUSIONS - Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.

Original language	English (US)
Pages (from-to)	851-853
Number of pages	3
Journal	Diabetes care
Volume	32
Issue number	5
DOIs	https://doi.org/10.2337/dc08-2059
State	Published - May 2009
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

Access to Document

10.2337/dc08-2059

Cite this

@article{a6c143df314944a49f26809c9a4803ff,

title = "Obesity and albuminuria among adults with type 2 diabetes: The look AHEAD (Action for Health in Diabetes) Study",

abstract = "OBJECTIVE - To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS - In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates. RESULTS - The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model. CONCLUSIONS - Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.",

author = "Holly Kramer and David Reboussin and Bertoni, {Alain G.} and Santica Marcovina and Edward Lipkin and Greenway, {Frank L.} and Brancati, {Frederick L.}",

year = "2009",

month = may,

doi = "10.2337/dc08-2059",

language = "English (US)",

volume = "32",

pages = "851--853",

journal = "Diabetes care",

issn = "0149-5992",

publisher = "American Diabetes Association Inc.",

number = "5",

}

TY - JOUR

T1 - Obesity and albuminuria among adults with type 2 diabetes

T2 - The look AHEAD (Action for Health in Diabetes) Study

AU - Kramer, Holly

AU - Reboussin, David

AU - Bertoni, Alain G.

AU - Marcovina, Santica

AU - Lipkin, Edward

AU - Greenway, Frank L.

AU - Brancati, Frederick L.

PY - 2009/5

Y1 - 2009/5

N2 - OBJECTIVE - To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS - In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates. RESULTS - The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model. CONCLUSIONS - Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.

AB - OBJECTIVE - To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. RESEARCH DESIGN AND METHODS - In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates. RESULTS - The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model. CONCLUSIONS - Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=65949095018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65949095018&partnerID=8YFLogxK

U2 - 10.2337/dc08-2059

DO - 10.2337/dc08-2059

M3 - Article

C2 - 19196893

AN - SCOPUS:65949095018

SN - 0149-5992

VL - 32

SP - 851

EP - 853

JO - Diabetes care

JF - Diabetes care

IS - 5

ER -

Obesity and albuminuria among adults with type 2 diabetes: The look AHEAD (Action for Health in Diabetes) Study

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this