O-linked N-acetylglucosamine and cancer: Messages from the glycosylation of c-Myc

T. Y. Chou, Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

Altered protein glycosylation is known to correlate with tumorigenesis, but its role remains enigmatic. Cells transformed by altered oncogene or tumor suppressor gene expression often also show changes of carbohydrate on cell surface glycoconjugates which correlate with the potential for tumor invasion and metastasis. In recent years, many oncogene and tumor suppressor gene products, such as c-Myc, SV40 large T antigen, and p53, were shown to be modified by O-GlcNAc. O-GlcNAc is a form of protein glycosylation found almost exclusively in the nucleus and cytoplasm of eukaryotic cells. The known O-GlcNAc-bearing proteins are phosphoproteins and form reversible multimeric complexes. O-GlcNAc modification is dynamic and appears to have a reciprocal relationship with protein phosphorylation. The enzymes which catalyze O-GlcNAc addition and removal have been characterized and used as effective tools in O-GlcNAc studies. It is of great interest in the future to investigate the alteration of O-GlcNAc in different cancers since addition/removal of O-GlcNAc on oncoproteins, tumor suppressor proteins, and other tumor-related proteins very likely plays a key role in the pathogenesis of tumors.

Original languageEnglish (US)
Pages (from-to)413-418
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume491
StatePublished - 2001

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Glycosylation
Acetylglucosamine
Tumors
Tumor Suppressor Genes
Oncogenes
Neoplasms
Proteins
Polyomavirus Transforming Antigens
Tumor Suppressor Proteins
Bearings (structural)
Glycoconjugates
Phosphoproteins
Oncogene Proteins
Viral Tumor Antigens
Eukaryotic Cells
Phosphorylation
Carcinogenesis
Cytoplasm
Gene expression
Carbohydrates

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

O-linked N-acetylglucosamine and cancer : Messages from the glycosylation of c-Myc. / Chou, T. Y.; Hart, Gerald Warren.

In: Advances in Experimental Medicine and Biology, Vol. 491, 2001, p. 413-418.

Research output: Contribution to journalArticle

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