O-Glcnacylation: Nutrient Sensor That Regulates Cell Physiology

Gerald Warren Hart

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

O-GlcNAcylation, which is the cycling of N-acetylglucosamine (GlcNAc) on nuclear and cytosolic proteins, has extensive cross talk with phosphorylation to serve as a nutrient sensor that regulates nearly all aspects of cellular metabolism. O-GlcNAc cycling is tightly regulated by only two gene products, O-GlcNAc transferase and O-GlcNAcase that are targeted to substrates by a multitude of binding partners. Research over the past three decades has shown that O-GlcNAcylation is fundamentally important in regulating transcription, modulating signaling pathways, andmodifying the activities ofmetabolic enzymes and kinases in response to nutrients.

Original languageEnglish (US)
Title of host publicationGlycoscience: Biology and Medicine
PublisherSpringer Japan
Pages1193-1199
Number of pages7
ISBN (Print)9784431548416, 9784431548409
DOIs
StatePublished - Jan 1 2015

Keywords

  • Kinases
  • Metabolism
  • Nutrient sensor
  • O-GlcNAc transferase
  • O-GlcNAcase
  • O-GlcNAcylation
  • Phosphorylation
  • Signaling
  • Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'O-Glcnacylation: Nutrient Sensor That Regulates Cell Physiology'. Together they form a unique fingerprint.

Cite this