O-GlcNAc signalling: Implications for cancer cell biology

Chad Slawson, Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

O-GlcNAcylation is the covalent attachment of Î 2-D-N- acetylglucosamine (GlcNAc) sugars to serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in extensive crosstalk with other post-translational modifications, such as phosphorylation. O-GlcNAcylation is becoming increasing realized as having important roles in cancer-relevant processes, such as cell signalling, transcription, cell division, metabolism and cytoskeletal regulation. However, currently little is known about the specific roles of aberrant O-GlcNAcylation in cancer. In this Opinion article, we summarize the current understanding of O-GlcNAcylation in cancer and its emerging functions in transcriptional regulation at the level of chromatin and transcription factors.

Original languageEnglish (US)
Pages (from-to)678-684
Number of pages7
JournalNature Reviews Cancer
Volume11
Issue number9
DOIs
StatePublished - Sep 2011

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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