O-GlcNAc modification of nucleocytoplasmic proteins and diabetes

Yoshihiro Akimoto, Gerald Warren Hart, Hiroshi Hirano, Hayato Kawakami

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear and cytosolic proteins are glycosylated on serine or threonine residues by O-linked β-N-acetylglucosamine (O-GlcNAc). O-GlcNAc modification is one of various posttranslational modifications and seems to be involved in the modulation of transcription and signal transduction. Accumulating data suggest a role for O-GlcNAc-modified proteins in diabetes, acting as a glucose sensor. It has been suggested that the hexosamine biosynthetic pathway is involved in the mechanism causing insulin resistance and diabetic complications. Excess glucose entering into the hexosamine biosynthetic pathway might cause elevated O-GlcNAc modification of various proteins. In this article, we review the current data regarding the relationship between O-GlcNAc modification and diabetes.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalMedical Molecular Morphology
Volume38
Issue number2
DOIs
StatePublished - 2005

Keywords

  • Aorta
  • Cornea
  • Diabetes
  • Glycosyltransferase
  • Hexosamine biosynthetic pathway
  • O-GlcNAc
  • Pancreas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

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