O-GlcNAc cycling: How a single sugar post-translational modification is changing the way we think about signaling networks

Chad Slawson, Michael P. Housley, Gerald Warren Hart

Research output: Contribution to journalArticlepeer-review

Abstract

O-GlcNAc is an ubiquitous post-translational protein modification consisting of a single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. This review will focus on recent work involving O-GlcNAc in sensing the environment and regulating signaling cascades.

Original languageEnglish (US)
Pages (from-to)71-83
Number of pages13
JournalJournal of Cellular Biochemistry
Volume97
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Cell cycle
  • Diabetes
  • O-GlcNAc
  • O-GlcNAc transferase
  • O-GlcNAcase
  • Phosphorylation
  • Signaling
  • Stress
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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