Abstract
O-GlcNAc is an ubiquitous post-translational protein modification consisting of a single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. This review will focus on recent work involving O-GlcNAc in sensing the environment and regulating signaling cascades.
Original language | English (US) |
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Pages (from-to) | 71-83 |
Number of pages | 13 |
Journal | Journal of Cellular Biochemistry |
Volume | 97 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2006 |
Keywords
- Cell cycle
- Diabetes
- O-GlcNAc
- O-GlcNAc transferase
- O-GlcNAcase
- Phosphorylation
- Signaling
- Stress
- Transcription
ASJC Scopus subject areas
- Biochemistry
- Cell Biology