NY-ESO-1 expression in sarcomas a diagnostic marker and immunotherapy target

Jin Ping Lai; Avi Z. Rosenberg; Markku M. Miettinen; Chyi Chia R. Lee

doi:10.4161/onci.21059

NY-ESO-1 expression in sarcomas a diagnostic marker and immunotherapy target

Jin Ping Lai, Avi Z. Rosenberg, Markku M. Miettinen, Chyi Chia R. Lee

Research output: Contribution to journal › Comment/debate › peer-review

31 Scopus citations

Abstract

NY-ES O-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ES O-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ES O-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.

Original language	English (US)
Pages (from-to)	1409-1410
Number of pages	2
Journal	OncoImmunology
Volume	1
Issue number	8
DOIs	https://doi.org/10.4161/onci.21059
State	Published - 2012
Externally published	Yes

Keywords

Cancer-testis antigen
Clinical trial
Diagnostic marker
Immunotherapy
Melanoma
NY-ESO-1
Sarcomas
Synovial sarcoma
T-cell receptor
Therapeutic target

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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title = "NY-ESO-1 expression in sarcomas a diagnostic marker and immunotherapy target",

abstract = "NY-ES O-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ES O-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ES O-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.",

keywords = "Cancer-testis antigen, Clinical trial, Diagnostic marker, Immunotherapy, Melanoma, NY-ESO-1, Sarcomas, Synovial sarcoma, T-cell receptor, Therapeutic target",

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AU - Lai, Jin Ping

AU - Rosenberg, Avi Z.

AU - Miettinen, Markku M.

AU - Lee, Chyi Chia R.

PY - 2012

Y1 - 2012

N2 - NY-ES O-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ES O-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ES O-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.

AB - NY-ES O-1 (CTAG 1B) is highly expressed in the majority of synovial sarcomas and myxoid/round cell liposarcomas as well as in a subset of melanomas, but only rarely in other mesenchymal tumors. This points to a potential for using NY-ES O-1 in the differential diagnosis of these lesions. Furthermore, promising results have been obtained in clinical trials testing NY-ES O-1-targeted immunotherapy in subsets of melanoma and synovial sarcoma patients.

KW - Cancer-testis antigen

KW - Clinical trial

KW - Diagnostic marker

KW - Immunotherapy

KW - Melanoma

KW - NY-ESO-1

KW - Sarcomas

KW - Synovial sarcoma

KW - T-cell receptor

KW - Therapeutic target

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M3 - Comment/debate

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JO - OncoImmunology

JF - OncoImmunology

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NY-ESO-1 expression in sarcomas a diagnostic marker and immunotherapy target

Abstract

Keywords

ASJC Scopus subject areas

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