TY - JOUR
T1 - NVL
T2 - A new member of the AAA family of ATPases localized to the nucleus
AU - Germain-Lee, Emily Lucy
AU - Obie, Cassandra
AU - Valle, David
N1 - Funding Information:
We thank Drs. Beth Torchia and Gail Stetten for FISH mapping. We also thank Sandy Muscelli for help in preparation of the manuscript. E.G.-L. is supported by an NIH Clinical Investigator Award (HD00989). D.V. is an Investigator with the Howard Hughes Medical Institute. This work was also suported by NIH Grant HD10981 to the Kennedy Krieger Institute.
PY - 1997/8/15
Y1 - 1997/8/15
N2 - We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W. H. Kunau et al., 1993, Biochimie 75: 209-224). NVL was isolated by degenerate PCR using oligonucleotides corresponding to the yeast PEX1 gene, which is necessary for peroxisomal biogenesis. Two cDNAs, designated NVL.1 and NVL.2, may represent alternatively spliced forms of a single gene that maps to chromosome lq41-q42.2.NVL has greatest similarity to the VCP subfamily of AAA proteins, is widely expressed, and encodes a nuclear protein with two highly similar ATP-binding domains. We speculate that NVLp is involved in an ATP-dependent nuclear process.
AB - We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W. H. Kunau et al., 1993, Biochimie 75: 209-224). NVL was isolated by degenerate PCR using oligonucleotides corresponding to the yeast PEX1 gene, which is necessary for peroxisomal biogenesis. Two cDNAs, designated NVL.1 and NVL.2, may represent alternatively spliced forms of a single gene that maps to chromosome lq41-q42.2.NVL has greatest similarity to the VCP subfamily of AAA proteins, is widely expressed, and encodes a nuclear protein with two highly similar ATP-binding domains. We speculate that NVLp is involved in an ATP-dependent nuclear process.
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U2 - 10.1006/geno.1997.4856
DO - 10.1006/geno.1997.4856
M3 - Article
C2 - 9286697
AN - SCOPUS:0031571599
SN - 0888-7543
VL - 44
SP - 22
EP - 34
JO - Genomics
JF - Genomics
IS - 1
ER -