Nutritional Factors in Corneal Xerophthalmia and Keratomalacia

Alfred Sommer, M. Muhilal

Research output: Contribution to journalArticle

Abstract

Six measures of nutritional status were studied in 162 consecutive cases of presumed nutritional keratopathy ranging from mild xerosis through full-thickness necrosis (keratomalacia) and in a variety of control subjects. The severity of corneal involvement was related to the severity of wasting, prevalence of edema, and serum levels of albumin, transferrin, and vitamin A. Even the most severe corneal alterations were compatible with normal indices of protein and anthropometric status, but not with normal serum vitamin A levels. Analysis suggests that interaction between vitamin A and protein status determines cellular adequacy of vitamin A metabolism, which virtually collapses in keratomalacia. Serum levels of holoretinol-binding protein were severely and uniformly depressed in all degrees of corneal involvement.

Original languageEnglish (US)
Pages (from-to)399-403
Number of pages5
JournalArchives of Ophthalmology
Volume100
Issue number3
DOIs
StatePublished - 1982

Fingerprint

Xerophthalmia
Vitamin A
Transferrin
Nutritional Status
Serum
Serum Albumin
Edema
Carrier Proteins
Proteins
Necrosis
Keratomalacia

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Nutritional Factors in Corneal Xerophthalmia and Keratomalacia. / Sommer, Alfred; Muhilal, M.

In: Archives of Ophthalmology, Vol. 100, No. 3, 1982, p. 399-403.

Research output: Contribution to journalArticle

@article{eb46b3b5484d4c87bcedb1256b47af78,
title = "Nutritional Factors in Corneal Xerophthalmia and Keratomalacia",
abstract = "Six measures of nutritional status were studied in 162 consecutive cases of presumed nutritional keratopathy ranging from mild xerosis through full-thickness necrosis (keratomalacia) and in a variety of control subjects. The severity of corneal involvement was related to the severity of wasting, prevalence of edema, and serum levels of albumin, transferrin, and vitamin A. Even the most severe corneal alterations were compatible with normal indices of protein and anthropometric status, but not with normal serum vitamin A levels. Analysis suggests that interaction between vitamin A and protein status determines cellular adequacy of vitamin A metabolism, which virtually collapses in keratomalacia. Serum levels of holoretinol-binding protein were severely and uniformly depressed in all degrees of corneal involvement.",
author = "Alfred Sommer and M. Muhilal",
year = "1982",
doi = "10.1001/archopht.1982.01030030401002",
language = "English (US)",
volume = "100",
pages = "399--403",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "3",

}

TY - JOUR

T1 - Nutritional Factors in Corneal Xerophthalmia and Keratomalacia

AU - Sommer, Alfred

AU - Muhilal, M.

PY - 1982

Y1 - 1982

N2 - Six measures of nutritional status were studied in 162 consecutive cases of presumed nutritional keratopathy ranging from mild xerosis through full-thickness necrosis (keratomalacia) and in a variety of control subjects. The severity of corneal involvement was related to the severity of wasting, prevalence of edema, and serum levels of albumin, transferrin, and vitamin A. Even the most severe corneal alterations were compatible with normal indices of protein and anthropometric status, but not with normal serum vitamin A levels. Analysis suggests that interaction between vitamin A and protein status determines cellular adequacy of vitamin A metabolism, which virtually collapses in keratomalacia. Serum levels of holoretinol-binding protein were severely and uniformly depressed in all degrees of corneal involvement.

AB - Six measures of nutritional status were studied in 162 consecutive cases of presumed nutritional keratopathy ranging from mild xerosis through full-thickness necrosis (keratomalacia) and in a variety of control subjects. The severity of corneal involvement was related to the severity of wasting, prevalence of edema, and serum levels of albumin, transferrin, and vitamin A. Even the most severe corneal alterations were compatible with normal indices of protein and anthropometric status, but not with normal serum vitamin A levels. Analysis suggests that interaction between vitamin A and protein status determines cellular adequacy of vitamin A metabolism, which virtually collapses in keratomalacia. Serum levels of holoretinol-binding protein were severely and uniformly depressed in all degrees of corneal involvement.

UR - http://www.scopus.com/inward/record.url?scp=0020041385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020041385&partnerID=8YFLogxK

U2 - 10.1001/archopht.1982.01030030401002

DO - 10.1001/archopht.1982.01030030401002

M3 - Article

C2 - 7065955

AN - SCOPUS:0020041385

VL - 100

SP - 399

EP - 403

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 3

ER -