Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection

Beth C. Tohill, Charles M. Heilig, Robert S. Klein, Anne Marie Rompalo, Susan Cu-Uvin, Ellen G. Piwoz, Denise J. Jamieson, Ann Duerr

Research output: Contribution to journalArticle

Abstract

Background: Women infected with HIV face a combination of health threats that include compromised nutrition and adverse gynecological conditions. This relation among HIV, nutrition, and gynecological conditions is complex and has rarely been investigated. Objective: Our objective was to investigate nutritional biomarkers associated with several gynecological conditions among US women with or at risk of HIV infection. Design: Data on 369 HIV-infected and 184 HIV-uninfected women with both nutritional and gynecological outcomes were analyzed from a cross-sectional nutritional substudy of the HIV Epidemiology Research Study (HERS). We examined micronutrient distributions comparing HIV-infected with HIV-uninfected participants and both subgroups with the US population. We then modeled the relation of 16 micronutrient serum concentrations to various gynecological conditions, producing partially adjusted odds ratios, adjusted for study site, risk cohort, and HIV status. Results: HIV-infected women's median antioxidant concentrations were lower than the medians of the US population. HERS women had lower median concentrations for vitamin A, selenium, and zinc irrespective of HIV status. Trichomoniasis prevalence was inversely related to serum α-carotene. Lower concentrations of vitamins A, C, and E and β-carotene were associated with an increased risk of bacterial vaginosis. Higher concentrations of serum zinc were associated with lower risk of human papillomavirus. Candida colonization was higher among women with higher concentrations of totaliron-binding capacity. Conclusion: We identified several significant associations of micronutrient concentrations with the prevalence of gynecological conditions. These findings warrant further investigation into possible causal relations.

Original languageEnglish (US)
Pages (from-to)1327-1334
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume85
Issue number5
StatePublished - May 1 2007

Fingerprint

HIV infections
HIV Infections
biomarkers
Biomarkers
HIV
dietary minerals
carotenes
Micronutrients
vitamin A
epidemiology
zinc
nutrition
trichomoniasis
Papillomaviridae
Carotenoids
Vitamin A
binding capacity
Candida
Zinc
odds ratio

Keywords

  • Bacterial vaginosis
  • Candida
  • HIV
  • HPV
  • Human papillomavirus
  • Nutritional status
  • Trichomoniasis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Tohill, B. C., Heilig, C. M., Klein, R. S., Rompalo, A. M., Cu-Uvin, S., Piwoz, E. G., ... Duerr, A. (2007). Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection. American Journal of Clinical Nutrition, 85(5), 1327-1334.

Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection. / Tohill, Beth C.; Heilig, Charles M.; Klein, Robert S.; Rompalo, Anne Marie; Cu-Uvin, Susan; Piwoz, Ellen G.; Jamieson, Denise J.; Duerr, Ann.

In: American Journal of Clinical Nutrition, Vol. 85, No. 5, 01.05.2007, p. 1327-1334.

Research output: Contribution to journalArticle

Tohill, BC, Heilig, CM, Klein, RS, Rompalo, AM, Cu-Uvin, S, Piwoz, EG, Jamieson, DJ & Duerr, A 2007, 'Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection', American Journal of Clinical Nutrition, vol. 85, no. 5, pp. 1327-1334.
Tohill, Beth C. ; Heilig, Charles M. ; Klein, Robert S. ; Rompalo, Anne Marie ; Cu-Uvin, Susan ; Piwoz, Ellen G. ; Jamieson, Denise J. ; Duerr, Ann. / Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection. In: American Journal of Clinical Nutrition. 2007 ; Vol. 85, No. 5. pp. 1327-1334.
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