TY - JOUR
T1 - Nutritional and immunological correlates of memory and neurocognitive development among HIV-infected children living in Kayunga, Uganda
AU - Ruiseñor-Escudero, Horacio
AU - Familiar-Lopez, Itziar
AU - Sikorskii, Alla
AU - Jambulingam, Nikita
AU - Nakasujja, Noelline
AU - Opoka, Robert
AU - Bass, Judith
AU - Boivin, Michael
N1 - Publisher Copyright:
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/3/23
Y1 - 2016/3/23
N2 - Objective: To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda. Design: This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1-6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda. Methods: Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers. Results: In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P = 0.04) were associated to higher immediate and total recall scores (P = 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P = 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P = 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL. Conclusions: Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.
AB - Objective: To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda. Design: This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1-6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda. Methods: Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers. Results: In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P = 0.04) were associated to higher immediate and total recall scores (P = 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P = 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P = 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL. Conclusions: Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.
KW - COAT
KW - Children
KW - HIV
KW - Immunological
KW - MSEL
KW - WAZ
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U2 - 10.1097/QAI.0000000000000905
DO - 10.1097/QAI.0000000000000905
M3 - Article
C2 - 26605506
AN - SCOPUS:84947996662
SN - 1525-4135
VL - 71
SP - 522
EP - 529
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 5
ER -