Nutritional and immunological correlates of memory and neurocognitive development among HIV-infected children living in Kayunga, Uganda

Horacio Ruiseñor-Escudero, Itziar Familiar-Lopez, Alla Sikorskii, Nikita Jambulingam, Noelline Nakasujja, Robert Opoka, Judith Bass, Michael Boivin

Research output: Contribution to journalArticle

Abstract

Objective: To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda. Design: This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1-6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda. Methods: Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers. Results: In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P = 0.04) were associated to higher immediate and total recall scores (P = 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P = 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P = 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL. Conclusions: Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.

Original languageEnglish (US)
Pages (from-to)522-529
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume71
Issue number5
DOIs
StatePublished - Mar 23 2016

Fingerprint

Immunologic Memory
Uganda
Learning
HIV
T-Lymphocytes
Color
HLA-DR Antigens
Linear Models
Biomarkers
Parenting
Short-Term Memory
Language
Randomized Controlled Trials
Weights and Measures

Keywords

  • Children
  • COAT
  • HIV
  • Immunological
  • MSEL
  • WAZ

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Nutritional and immunological correlates of memory and neurocognitive development among HIV-infected children living in Kayunga, Uganda. / Ruiseñor-Escudero, Horacio; Familiar-Lopez, Itziar; Sikorskii, Alla; Jambulingam, Nikita; Nakasujja, Noelline; Opoka, Robert; Bass, Judith; Boivin, Michael.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 71, No. 5, 23.03.2016, p. 522-529.

Research output: Contribution to journalArticle

Ruiseñor-Escudero, Horacio ; Familiar-Lopez, Itziar ; Sikorskii, Alla ; Jambulingam, Nikita ; Nakasujja, Noelline ; Opoka, Robert ; Bass, Judith ; Boivin, Michael. / Nutritional and immunological correlates of memory and neurocognitive development among HIV-infected children living in Kayunga, Uganda. In: Journal of Acquired Immune Deficiency Syndromes. 2016 ; Vol. 71, No. 5. pp. 522-529.
@article{719f3eb03b194eee9f879371a1fbf2da,
title = "Nutritional and immunological correlates of memory and neurocognitive development among HIV-infected children living in Kayunga, Uganda",
abstract = "Objective: To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda. Design: This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1-6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda. Methods: Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers. Results: In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P = 0.04) were associated to higher immediate and total recall scores (P = 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P = 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P = 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL. Conclusions: Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.",
keywords = "Children, COAT, HIV, Immunological, MSEL, WAZ",
author = "Horacio Ruise{\~n}or-Escudero and Itziar Familiar-Lopez and Alla Sikorskii and Nikita Jambulingam and Noelline Nakasujja and Robert Opoka and Judith Bass and Michael Boivin",
year = "2016",
month = "3",
day = "23",
doi = "10.1097/QAI.0000000000000905",
language = "English (US)",
volume = "71",
pages = "522--529",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Nutritional and immunological correlates of memory and neurocognitive development among HIV-infected children living in Kayunga, Uganda

AU - Ruiseñor-Escudero, Horacio

AU - Familiar-Lopez, Itziar

AU - Sikorskii, Alla

AU - Jambulingam, Nikita

AU - Nakasujja, Noelline

AU - Opoka, Robert

AU - Bass, Judith

AU - Boivin, Michael

PY - 2016/3/23

Y1 - 2016/3/23

N2 - Objective: To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda. Design: This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1-6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda. Methods: Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers. Results: In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P = 0.04) were associated to higher immediate and total recall scores (P = 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P = 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P = 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL. Conclusions: Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.

AB - Objective: To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda. Design: This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1-6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda. Methods: Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers. Results: In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P = 0.04) were associated to higher immediate and total recall scores (P = 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P = 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P = 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL. Conclusions: Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.

KW - Children

KW - COAT

KW - HIV

KW - Immunological

KW - MSEL

KW - WAZ

UR - http://www.scopus.com/inward/record.url?scp=84947996662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947996662&partnerID=8YFLogxK

U2 - 10.1097/QAI.0000000000000905

DO - 10.1097/QAI.0000000000000905

M3 - Article

C2 - 26605506

AN - SCOPUS:84947996662

VL - 71

SP - 522

EP - 529

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 5

ER -