Abstract
Nutrients regulate gene transcription by the dynamic cycling of O-linked Nacetylglucosamine (O-GlcNAc) on proteins that constitute the transcriptional machinery. A study shows that O-GlcNAcylation of the nuclear factor êB (NF-êB) subunit c-Rel is required for its binding to the promoters of some, but not all, key T cell receptor-dependent genes; however, O-GlcNAcylation is dispensable for the binding of c-Rel to the promoters of tumor necrosis factor-á-dependent genes. This study not only illustrates how specifi c stimuli that act on the same transcription factor can elicit the expression of particular sets of genes, it also suggests a possible mechanism for autoimmunity in diabetes.
Original language | English (US) |
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Article number | pe26 |
Journal | Science Signaling |
Volume | 6 |
Issue number | 290 |
DOIs | |
State | Published - Aug 27 2013 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology