Nutrient regulation of immunity: O-GlcNAcylation regulates stimulus-specific NF-κB-Dependent transcription

Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

Nutrients regulate gene transcription by the dynamic cycling of O-linked Nacetylglucosamine (O-GlcNAc) on proteins that constitute the transcriptional machinery. A study shows that O-GlcNAcylation of the nuclear factor êB (NF-êB) subunit c-Rel is required for its binding to the promoters of some, but not all, key T cell receptor-dependent genes; however, O-GlcNAcylation is dispensable for the binding of c-Rel to the promoters of tumor necrosis factor-á-dependent genes. This study not only illustrates how specifi c stimuli that act on the same transcription factor can elicit the expression of particular sets of genes, it also suggests a possible mechanism for autoimmunity in diabetes.

Original languageEnglish (US)
Article numberpe26
JournalScience Signaling
Volume6
Issue number290
DOIs
StatePublished - Aug 27 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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