Nutrient regulation of gene expression by O-GlcNAcylation of chromatin

Stéphan Hardivillé, Gerald W. Hart

Research output: Contribution to journalReview articlepeer-review

Abstract

O-GlcNAcylation is a dynamic post-translational modification that is responsive to nutrient availably via the hexosamine biosynthetic pathway and its endproduct UDP-GlcNAc. O-GlcNAcylation serves as a nutrient sensor to regulate the activities of many proteins involved in nearly all biological processes. Within the last decade, OGT, OGA and O-GlcNAcylation have been shown to be at the nexus of epigenetic marks controlling gene expression during embryonic development, cell differentiation, in the maintenance of epigenetic states and in the etiology of epigenetic related diseases. OGT O-GlcNAcylates histones and epigenetic writers/erasers, and regulates gene activation, as well as gene repression. Here, we highlight recent work documenting the important roles O-GlcNAcylation and its cycling enzymes play in the nutrient regulation of epigenetic partners controlling gene expression.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume33
DOIs
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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