Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells

T. D G Lee, A. Sterk, T. Ishizaka, J. Bienenstock, A. D. Befus

Research output: Contribution to journalArticle

Abstract

Recently, particular attention has been paid to a unique subpopulation of mast cells located in the intestinal mucosa of rodents and man. These cells, presently referred to as mucosal mast cells (MMC), are morphologically, histochemically and functionally distinct from the more extensively studied connective tissue mast cells. Our ability to characterize the MMC more fully has been markedly enhanced by the development of techniques to enrich populations of this cell to purities of over 60% (mean 65.6 ± 5.2%) using density centrifugation over discontinuous Percoll gradients. In this communication, we report the results of our studies to determine the number and affinity characteristics of IgG Fc (Fc(ε)) receptors on enriched MMC isolated from the intestine of rats with parasite-induced mast cell hyperplasia.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalImmunology
Volume55
Issue number2
StatePublished - 1985
Externally publishedYes

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IgE Receptors
Mast Cells
Population
Connective Tissue Cells
IgG Receptors
Fc Receptors
Intestinal Mucosa
Centrifugation
Intestines
Hyperplasia
Rodentia
Parasites

ASJC Scopus subject areas

  • Immunology

Cite this

Lee, T. D. G., Sterk, A., Ishizaka, T., Bienenstock, J., & Befus, A. D. (1985). Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells. Immunology, 55(2), 363-366.

Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells. / Lee, T. D G; Sterk, A.; Ishizaka, T.; Bienenstock, J.; Befus, A. D.

In: Immunology, Vol. 55, No. 2, 1985, p. 363-366.

Research output: Contribution to journalArticle

Lee, TDG, Sterk, A, Ishizaka, T, Bienenstock, J & Befus, AD 1985, 'Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells', Immunology, vol. 55, no. 2, pp. 363-366.
Lee TDG, Sterk A, Ishizaka T, Bienenstock J, Befus AD. Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells. Immunology. 1985;55(2):363-366.
Lee, T. D G ; Sterk, A. ; Ishizaka, T. ; Bienenstock, J. ; Befus, A. D. / Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells. In: Immunology. 1985 ; Vol. 55, No. 2. pp. 363-366.
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