Nucleic acid-based methods for the detection of cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Continued elucidation of the genetic changes that drive cancer progression is yielding new and potentially powerful nucleic acid-based markers of neoplastic disease. Pilot studies indicate that these markers can be used to detect cancer cells in a variety of clinical settings with unprecedented precision. Nucleic acid-based markers may prove to be valuable tools for early detection of cancer in asymptomatic individuals, for confirmation or exclusion of a cancer diagnosis that is based on suspicious but nondiagnostic clinical material, for assessment of tumor burden n cancer patients, and for assessment of response to preventive approaches applied to healthy individuals who are at high risk of developing cancer. Examples of these markers, their potential applications, and the current practical limitations on their clinical use are reviewed here.

Original languageEnglish (US)
Pages (from-to)1054-1058
Number of pages5
JournalScience
Volume278
Issue number5340
DOIs
StatePublished - Nov 7 1997

ASJC Scopus subject areas

  • General

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