Nuclear Morphometry for Prediction of Metastatic Potential in Early Squamous Cell Carcinoma of the Floor of the Mouth

Robert J.S. Briggs, Kenneth J. Pienta, Ralph H. Hruban, William J. Richtsmeier

Research output: Contribution to journalArticle


Quantitative morphometric analyses of the nuclear shape have been successfully used with prostatic carcinoma to predict tumor metastatic potential and provide the most sensitive indicator of tumor aggressiveness in the individual case. We have studied the nuclear morphometric characteristics of 22 patients with T1 and T2 squamous cell carcinoma of the floor of the mouth to see if a correlation existed between lack of nuclear roundness and presence of cervical metastatic disease. A significant difference was identified between the morphology of cancer cell nuclei and normal squamous epithelium. Nuclear morphology could not be used to distinguish between patients with cervical node-negative and node-positive disease. Some patients both with and without cervical metastates who are long-term survivors had nuclear roundness scores in the highest range, reflecting greatest variation from normal.

Original languageEnglish (US)
Pages (from-to)531-533
Number of pages3
JournalArchives of Otolaryngology--Head and Neck Surgery
Issue number5
StatePublished - May 1992


ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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