Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer

Robert W. Veltri, Christhunesa S. Christudass

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nuclear structure alterations in cancer involve global genetic (mutations, amplifications, copy number variations, translocations, etc.) and epigenetic (DNA methylation and histone modifications) events that dramatically and dynamically spatially change chromatin, nuclear body, and chromosome organization. In prostate cancer (CaP) there appears to be early (<50 years) versus late (>60 years) onset clinically significant cancers, and we have yet to clearly understand the hereditary and somatic-based molecular pathways involved. We do know that once cancer is initiated, dedifferentiation of the prostate gland occurs with significant changes in nuclear structure driven by numerous genetic and epigenetic processes. This review focuses upon the nuclear architecture and epigenetic dynamics with potential translational clinically relevant applications to CaP. Further, the review correlates changes in the cancer-driven epigenetic process at the molecular level and correlates these alterations to nuclear morphological quantitative measurements. Finally, we address how we can best utilize this knowledge to improve the efficacy of personalized treatment of cancer.

Original languageEnglish (US)
Title of host publicationCancer Biology and the Nuclear Envelope
Subtitle of host publicationRecent Advances May Elucidate Past Paradoxes
PublisherSpringer New York LLC
Pages77-99
Number of pages23
ISBN (Print)9781489980311
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume773
ISSN (Print)0065-2598

Keywords

  • Epigenetics
  • Nuclear morphology
  • Nuclear roundness
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Veltri, R. W., & Christudass, C. S. (2014). Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer. In Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (pp. 77-99). (Advances in Experimental Medicine and Biology; Vol. 773). Springer New York LLC. https://doi.org/10.1007/978-1-4899-8032-8_4