Nuclear localization of histamine in neonatal rat brain

Anne B. Young, Candace D. Pert, David G. Brown, Kenneth M. Taylor, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

The concentration of histamine in the brains of neonatal rats is considerably higher than that in adults. Subcellular fractionation studies revealed that about 90 percent of the histamine content of neonatal rat brain is confined to the crude nuclear fraction obtained by differential fractionation. Purified nuclei prepared from these fractions retained 90 percent of their histamine content. The nuclear localization of histamine in the brains of neonatal rats suggests a function for histamine in modulating the growth processes of the neonatal brain.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalScience
Volume173
Issue number3993
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • General

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