Nuclear imaging in cardiac cell therapy

Frank M. Bengel

Research output: Contribution to journalArticle

Abstract

Cardiac stem cell therapy is an innovative and promising therapeutic approach for heart failure. However, despite an increasing body of existing experimental and human data, it still presents a substantial challenge for basic scientists and clinical researchers. Several issues concerning biologic mechanisms of therapy remain to be answered, and unequivocal proof of clinical efficacy is needed. The variety of different available cell types and different methods for cell delivery to the myocardium raises further questions about the most useful therapeutic approach. Nuclear imaging not only provides accurate noninvasive information about myocardial perfusion, contractile function and viability, which enables assessment of clinical benefits of therapy. The rapidly developing field of molecular imaging has also brought up more specific tracers targeting cellular and subcellular biologic events, which are expected to shed more light upon mechanisms of cell therapy. Moreover, nuclear imaging is well suited for tracking of transplanted cells by use of direct radionuclide labeling or genetic labeling with reporter genes that can be targeted by radioactive reporter probes. Such a broad spectrum of available in vivo information is expected to significantly impact the future development of cell therapy towards a clinically accepted treatment.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalHeart Failure Reviews
Volume11
Issue number4
DOIs
StatePublished - Dec 2006

Fingerprint

Cell- and Tissue-Based Therapy
Cell Tracking
Biological Therapy
Molecular Imaging
Therapeutics
Reporter Genes
Radioisotopes
Myocardium
Stem Cells
Heart Failure
Perfusion
Research Personnel

Keywords

  • Cardiac regeneration
  • Molecular imaging
  • Radionuclide imaging
  • Stem cell therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nuclear imaging in cardiac cell therapy. / Bengel, Frank M.

In: Heart Failure Reviews, Vol. 11, No. 4, 12.2006, p. 325-332.

Research output: Contribution to journalArticle

Bengel, Frank M. / Nuclear imaging in cardiac cell therapy. In: Heart Failure Reviews. 2006 ; Vol. 11, No. 4. pp. 325-332.
@article{9f71271eec6e49c493bef75579b6b83a,
title = "Nuclear imaging in cardiac cell therapy",
abstract = "Cardiac stem cell therapy is an innovative and promising therapeutic approach for heart failure. However, despite an increasing body of existing experimental and human data, it still presents a substantial challenge for basic scientists and clinical researchers. Several issues concerning biologic mechanisms of therapy remain to be answered, and unequivocal proof of clinical efficacy is needed. The variety of different available cell types and different methods for cell delivery to the myocardium raises further questions about the most useful therapeutic approach. Nuclear imaging not only provides accurate noninvasive information about myocardial perfusion, contractile function and viability, which enables assessment of clinical benefits of therapy. The rapidly developing field of molecular imaging has also brought up more specific tracers targeting cellular and subcellular biologic events, which are expected to shed more light upon mechanisms of cell therapy. Moreover, nuclear imaging is well suited for tracking of transplanted cells by use of direct radionuclide labeling or genetic labeling with reporter genes that can be targeted by radioactive reporter probes. Such a broad spectrum of available in vivo information is expected to significantly impact the future development of cell therapy towards a clinically accepted treatment.",
keywords = "Cardiac regeneration, Molecular imaging, Radionuclide imaging, Stem cell therapy",
author = "Bengel, {Frank M.}",
year = "2006",
month = "12",
doi = "10.1007/s10741-006-0233-y",
language = "English (US)",
volume = "11",
pages = "325--332",
journal = "Heart Failure Reviews",
issn = "1382-4147",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Nuclear imaging in cardiac cell therapy

AU - Bengel, Frank M.

PY - 2006/12

Y1 - 2006/12

N2 - Cardiac stem cell therapy is an innovative and promising therapeutic approach for heart failure. However, despite an increasing body of existing experimental and human data, it still presents a substantial challenge for basic scientists and clinical researchers. Several issues concerning biologic mechanisms of therapy remain to be answered, and unequivocal proof of clinical efficacy is needed. The variety of different available cell types and different methods for cell delivery to the myocardium raises further questions about the most useful therapeutic approach. Nuclear imaging not only provides accurate noninvasive information about myocardial perfusion, contractile function and viability, which enables assessment of clinical benefits of therapy. The rapidly developing field of molecular imaging has also brought up more specific tracers targeting cellular and subcellular biologic events, which are expected to shed more light upon mechanisms of cell therapy. Moreover, nuclear imaging is well suited for tracking of transplanted cells by use of direct radionuclide labeling or genetic labeling with reporter genes that can be targeted by radioactive reporter probes. Such a broad spectrum of available in vivo information is expected to significantly impact the future development of cell therapy towards a clinically accepted treatment.

AB - Cardiac stem cell therapy is an innovative and promising therapeutic approach for heart failure. However, despite an increasing body of existing experimental and human data, it still presents a substantial challenge for basic scientists and clinical researchers. Several issues concerning biologic mechanisms of therapy remain to be answered, and unequivocal proof of clinical efficacy is needed. The variety of different available cell types and different methods for cell delivery to the myocardium raises further questions about the most useful therapeutic approach. Nuclear imaging not only provides accurate noninvasive information about myocardial perfusion, contractile function and viability, which enables assessment of clinical benefits of therapy. The rapidly developing field of molecular imaging has also brought up more specific tracers targeting cellular and subcellular biologic events, which are expected to shed more light upon mechanisms of cell therapy. Moreover, nuclear imaging is well suited for tracking of transplanted cells by use of direct radionuclide labeling or genetic labeling with reporter genes that can be targeted by radioactive reporter probes. Such a broad spectrum of available in vivo information is expected to significantly impact the future development of cell therapy towards a clinically accepted treatment.

KW - Cardiac regeneration

KW - Molecular imaging

KW - Radionuclide imaging

KW - Stem cell therapy

UR - http://www.scopus.com/inward/record.url?scp=33751513037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751513037&partnerID=8YFLogxK

U2 - 10.1007/s10741-006-0233-y

DO - 10.1007/s10741-006-0233-y

M3 - Article

C2 - 17131078

AN - SCOPUS:33751513037

VL - 11

SP - 325

EP - 332

JO - Heart Failure Reviews

JF - Heart Failure Reviews

SN - 1382-4147

IS - 4

ER -