@inbook{0887ba53ed854c409b578c32a8ab4024,
title = "Nuclear envelope in nuclear positioning and cell migration",
abstract = "Hauling and anchoring the nucleus within immobile or motile cells, tissues, and/or syncytia represents a major challenge. In the past 15 years, Linkers of the Nucleoskeleton to the Cytoskeleton (LINC complexes) have emerged as evolutionary-conserved molecular devices that span the nuclear envelope and provide interacting interfaces for cytoskeletal networks and molecular motors to the nuclear envelope. Here, we review the molecular composition of LINC complexes and focus on how their genetic alteration in vivo has provided a wealth of information related to the relevance of nuclear positioning during tissue development and homeostasis with a special emphasis on the central nervous system. As it may be relevant for metastasis in a range of cancers, the involvement of LINC complexes in migration of nonneuronal cells via its interaction with the perinuclear actin cap will also be developed.",
keywords = "Actin cap, Cell motility, Interkinetic nuclear migration, KASH domain, LINC complexes, Nesprin, Neuronal migration, Nuclear anchorage, Nuclear lamina, Retina, SUN domain, Skeletal muscle, Sun protein",
author = "David Razafsky and Denis Wirtz and Didier Hodzic",
note = "Funding Information: The authors are supported by the National Institute of Health (R01GM084204 to D.W. and D.H., R01CA174388 and U54CA143868 to D.W., R01EY022632 to D.H.) and by NIH training grant T32EY013360, core grant P30EY002687 and Unrestricted Grants from Research to Prevent Blindness, Inc. awarded to the Department of Ophthalmology and Visual Sciences at Washington University School of Medicine.",
year = "2014",
doi = "10.1007/978-1-4899-8032-8_21",
language = "English (US)",
isbn = "9781489980311",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "471--490",
booktitle = "Cancer Biology and the Nuclear Envelope",
}