TY - JOUR
T1 - Nuclear envelope assembly after mitosis
AU - Marshall, Ian C.B.
AU - Wilson, Katherine L.
PY - 1997/2
Y1 - 1997/2
N2 - In higher eukaryotes, the entire nucleus disassembles during prometaphase of the cell cycle and later reassembles around daughter chromosomes. Remarkably, the complex events that occur to create a functional nucleus in vivo can be duplicated in vitro by using cell-free extracts. Current experiments are aimed at understanding the molecular mechanisms of assembly and disassembly of the nuclear pore complexes and nuclear membranes, and the functional roles of four identified inner membrane proteins, two of which bind to both chromatin and the nuclear lamina.
AB - In higher eukaryotes, the entire nucleus disassembles during prometaphase of the cell cycle and later reassembles around daughter chromosomes. Remarkably, the complex events that occur to create a functional nucleus in vivo can be duplicated in vitro by using cell-free extracts. Current experiments are aimed at understanding the molecular mechanisms of assembly and disassembly of the nuclear pore complexes and nuclear membranes, and the functional roles of four identified inner membrane proteins, two of which bind to both chromatin and the nuclear lamina.
UR - http://www.scopus.com/inward/record.url?scp=0031081298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031081298&partnerID=8YFLogxK
U2 - 10.1016/S0962-8924(96)10047-7
DO - 10.1016/S0962-8924(96)10047-7
M3 - Review article
C2 - 17708909
AN - SCOPUS:0031081298
SN - 0962-8924
VL - 7
SP - 69
EP - 74
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -