Nuclear DNA damage signalling to mitochondria in ageing

Evandro Fei Fang, Morten Scheibye-Knudsen, Katrin F. Chua, Mark P. Mattson, Deborah L. Croteau, Vilhelm A. Bohr

Research output: Contribution to journalArticle

Abstract

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.

Original languageEnglish (US)
JournalNature Reviews Molecular Cell Biology
DOIs
StateAccepted/In press - Mar 9 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (Accepted/In press). Nuclear DNA damage signalling to mitochondria in ageing. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm.2016.14