Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors

Nathan Congdon, Karl W. Broman, Hong Chen Lai, Beatriz Munoz, Heidi Bowie, Donna Gilber, Robert Wojciechowski, Christine Alston, Sheila K West

Research output: Contribution to journalArticle

Abstract

PURPOSE. To quantify the association between siblings in age-related nuclear cataract, after adjusting for known environmental and personal risk factors. METHODS. All participants (probands) in the Salisbury Eye Evaluation (SEE) project and their locally resident siblings underwent digital slit lamp photography and were administered a questionnaire to assess risk factors for cataract including: age, gender, lifetime sun exposure, smoking and diabetes history, and use of alcohol and medications such as estrogens and steroids. In addition, blood pressure, body mass index, and serum antioxidants were measured in all participants. Lens photographs were graded by trained observers masked to the subjects' identity, using the Wilmer Cataract Grading System. The odds ratio for siblings for affectedness with nuclear cataract and the sibling correlation of nuclear cataract grade, after adjusting for covariates, were estimated with generalized estimating equations. RESULTS. Among 307 probands (mean age, 77.6 ± 4.5 years) and 434 full siblings (mean age, 72.4 ± 7.4 years), the average sibship size was 2.7 per family. After adjustment for covariates, the probability of development of nuclear cataract was significantly increased (odds ratio [OR] = 2.07, 95% confidence interval [CI], 1.30-3.30) among individuals with a sibling with nuclear cataract (nuclear grade ≥ 3.0). The final fitted model indicated a magnitude of heritability for nuclear cataract of 35.6% (95% CI: 21.0%-50.3%) after adjustment for the covariates. CONCLUSIONS. Findings in this study are consistent with a genetic effect for age-related nuclear cataract, a common and clinically significant form of lens opacity.

Original languageEnglish (US)
Pages (from-to)2182-2186
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume45
Issue number7
DOIs
StatePublished - Jul 2004

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Cataract
Population
Odds Ratio
Confidence Intervals
Photography
Solar System
Lenses
Estrogens
Body Mass Index
Antioxidants
Smoking
History
Steroids
Alcohols
Blood Pressure
Serum

ASJC Scopus subject areas

  • Ophthalmology

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Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors. / Congdon, Nathan; Broman, Karl W.; Lai, Hong Chen; Munoz, Beatriz; Bowie, Heidi; Gilber, Donna; Wojciechowski, Robert; Alston, Christine; West, Sheila K.

In: Investigative Ophthalmology and Visual Science, Vol. 45, No. 7, 07.2004, p. 2182-2186.

Research output: Contribution to journalArticle

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AU - Congdon, Nathan

AU - Broman, Karl W.

AU - Lai, Hong Chen

AU - Munoz, Beatriz

AU - Bowie, Heidi

AU - Gilber, Donna

AU - Wojciechowski, Robert

AU - Alston, Christine

AU - West, Sheila K

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N2 - PURPOSE. To quantify the association between siblings in age-related nuclear cataract, after adjusting for known environmental and personal risk factors. METHODS. All participants (probands) in the Salisbury Eye Evaluation (SEE) project and their locally resident siblings underwent digital slit lamp photography and were administered a questionnaire to assess risk factors for cataract including: age, gender, lifetime sun exposure, smoking and diabetes history, and use of alcohol and medications such as estrogens and steroids. In addition, blood pressure, body mass index, and serum antioxidants were measured in all participants. Lens photographs were graded by trained observers masked to the subjects' identity, using the Wilmer Cataract Grading System. The odds ratio for siblings for affectedness with nuclear cataract and the sibling correlation of nuclear cataract grade, after adjusting for covariates, were estimated with generalized estimating equations. RESULTS. Among 307 probands (mean age, 77.6 ± 4.5 years) and 434 full siblings (mean age, 72.4 ± 7.4 years), the average sibship size was 2.7 per family. After adjustment for covariates, the probability of development of nuclear cataract was significantly increased (odds ratio [OR] = 2.07, 95% confidence interval [CI], 1.30-3.30) among individuals with a sibling with nuclear cataract (nuclear grade ≥ 3.0). The final fitted model indicated a magnitude of heritability for nuclear cataract of 35.6% (95% CI: 21.0%-50.3%) after adjustment for the covariates. CONCLUSIONS. Findings in this study are consistent with a genetic effect for age-related nuclear cataract, a common and clinically significant form of lens opacity.

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